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Table 3 Clinicopathologic features as factors of elevated Hcy by univariate and multivariate logistic regression analysis

From: Serum homocysteine is associated with tubular interstitial lesions at the early stage of IgA nephropathy

Variables

Univariate

Multivariate

Overall

eGFR≥90 ml/min/1.73 m2

Odds ratio (95% CI)

P

Odds ratio (95% CI)

P

Odds ratio (95%CI)

P

Age

1.04 (1.02-1.06)

< 0.001**

    

Male

3.03 (1.83-5.02)

< 0.001**

3.47 (1.86-6.48)

< 0.001**

5.31 (2.23-12.64)

< 0.001**

MAP

1.04 (1.02-1.05)

< 0.001**

    

Scr

1.07 (1.05-1.09)

< 0.001**

    

eGFR

0.95 (0.94-0.96)

< 0.001**

0.95 (0.94-0.97)

< 0.001**

0.95 (0.91-0.98)

0.003*

BUN

1.66 (1.40-1.98)

< 0.001**

    

UA

1.01 (1.00-1.01)

< 0.001**

    

24-h urine protein

1.00 (0.94-1.08)

0.929

    

Hb

0.99 (0.98-1.00)

0.085

    

ALB

1.04 (1.01-1.08)

0.013*

1.07 (1.03-1.12)

0.001*

1.10 (1.04-1.16)

0.001*

Glu

0.91 (0.60-1.36)

0.630

    

CHOL

0.87 (0.77-1.00)

0.042*

    

TG

1.24 (0.98-1.58)

0.079

    

LDL

0.83 (0.69-1.01)

0.061

    

HDL

0.31 (0.16-0.61)

0.001*

    

SOD

1.00 (0.99-1.00)

0.241

    

hsCRP

1.01 (0.98-1.04)

0.429

    

ESR

1.01 (1.00-1.02)

0.033*

    

Ig A

1.04 (0.85-1.28)

0.694

    

Ig M

0.63 (0.42-0.95)

0.027*

    

Ig G

1.07 (1.00-1.14)

0.068

    

C3

1.00 (1.00-1.00)

0.126

    

C4

1.00 (1.00-1.00)

0.288

    

M0

1 (reference)

     

M1

1.07 (0.39-2.97)

0.896

    

E0

1 (reference)

     

E1

1.91 (1.02-3.57)

0.044*

    

S0

1 (reference)

     

S1

1.16 (0.73-1.85)

0.532

    

T0

1 (reference)

 

1 (reference)

 

1 (reference)

 

T1-2

9.13 (4.24-19.66)

< 0.001**

2.87 (1.20-6.89)

0.018*

14.20 (1.68-120.03)

0.015*

C0

1 (reference)

     

C1-2

1.19 (0.76-1.87)

0.451

    
  1. Abbreviations: MAP mean arterial pressure, Scr serum creatinine, eGFR estimated glomerular filtration rate, BUN blood urine nitrogen, UA uric acid, Hb hemoglobin, ALB serum albumin, Glu fasting glucose, CHOL cholesterol, TG triglyceride, LDL low-density lipoprotein-cholesterol, HDL high-density lipoprotein-cholesterol, SOD superoxide dismutase, hsCRP high sensitivity C reaction protein, ESR erythrocyte sedimentatio rate, IgA immunoglobulin A, IgM immunoglobulin M, IgG immunoglobulin G, C3 complement3, C4 complement4, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental glomerulosclerosis, T tubular atrophy and interstitial fibrosis, C crescents
  2. *P < 0.05, **P < 0.001
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BMC Nephrology

ISSN: 1471-2369

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