Table 1 Summary of reported SCC-TMA cases in overlap syndrome
Current case | Case 1 | Case 2 | Case 3 | Case 4 | Case 5 | |
|---|---|---|---|---|---|---|
Author | – | Hongrui Dong | Jordana Cheta | Greenberg | Yuki Nanke | Carlos Quereda |
Year | – | 2020 | 2017 | 2001 | 2000 | 1991 |
Age (year) | 21 | 61 | 50 | 64 | 33 | 47 |
Gender | Female | Male | Female | Female | Female | Female |
CTD | SCC-SLE-PM | SCC-SLE | MCTD | SCC-DM | SCC-SLE-RA | SCC-PM |
CTD History | 0y | 5y | 10y | 0y | 7y | 2y |
Other organs | – | CHF ILD | – | – | DAH | ILD |
Renal pathology | Stenosis and ischemia in glomerular capillary loops; moderately thickened vessels; edema endothelial, intimal thickening and occlusion in arteries. | Mucinous edema and “onion bulbs” in interlobular arteries; widened loose layer of glomerular basement membrane. | 1/9 glomerulus had a thrombus within an afferent arteriole; moderately thickened vessels; multiple red cell casts and dilated tubules. | Severe thrombotic and mesangiolysis in glomerular; multiple sclerosis or occluded vascular lumen with thrombi; focal tubular necrosis. | Multiple thrombi in afferent arterioles of glomeruli; fibrous and edematous arteries. | Multiple thrombi in glomerular capillary loops; endothelial proliferation, intimal thickening and thrombi occlusion in arteries. |
Treatment | CS, RASI, HD-PD, RTX | CS, CTX, RASI | CS, RASI, HD | CS, RASI, HD | CS, CTX, RASI HD, PE | CTX, RASI, HD-PD |
Prognosis | Normal renal function | Death | Normal renal function | Dependent on dialysis | Death | Dependent on dialysis |