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Table 1 Perioperative characteristics of patients between the training set and validation set

From: Prediction of chronic kidney disease after orthotopic liver transplantation: development and validation of a nomogram model

Characteristic

Training set

(n = 293)

Validation set

(n = 106)

p-value

Demographic data

 Age (years)

52 (46-59)

51 (44-58)

0.27

 Gender (N,%)

  

0.65

  Female

52 (17.7%)

16 (15.1%)

 

  Male

241 (82.3%)

90 (84.9%)

 

 BMI (Kg/m2)

24.22 (22.32-26.40)

23.69 (21.11-26.61)

0.40

 MAP (mmHg)

92 (85-98)

91 (84-97)

0.96

 Personal history

  Smoking (N,%)

125 (42.7%)

53 (50.0%)

0.21

  Alcoholism (N,%)

140 (47.8%)

52 (49.1%)

0.82

Pathogenesis of liver disease

 HBV hepatitis (N,%)

229 (78.2%)

82 (77.4%)

0.89

 Alcoholic liver cirrhosis (N,%)

21 (7.2%)

8 (7.5%)

1.00

 Hepatocellular carcinoma (N,%)

139 (47.4%)

57 (53.8%)

0.31

 Cholestatic disease (N,%)

19 (6.5%)

4 (3.8%)

0.47

 Liver complications

  Encephalopathy (N,%)

44 (15.0%)

11 (10.4%)

0.26

  Ascites> 1 L (N,%)

25 (23.6%)

71 (24.2%)

1.00

Baseline medical status

 Diabetes mellitus (N,%)

55 (18.8%)

21 (19.8%)

0.89

 Hypertension (N,%)

38 (13.0%)

12 (11.3%)

0.73

 Coronary heart disease (N,%)

8 (2.7%)

5 (4.7%)

0.34

 Abdominal surgery history (N,%)

29 (27.4%)

62 (21.2%)

0.22

 Preoperative LVEF (%)

63 (61, 65)

62 (60, 64)

0.10

 Preoperative nonselective β receptor blockers (N,%)

24 (8.2%)

7 (6.6%)

0.68

 Preoperative diuretics (N,%)

110 (37.5%)

30 (28.3%)

0.10

Preoperative scores

 MELD score

12.94 (9.50-18.87)

12.59 (9.50-17.00)

0.31

 Child-Pugh score

10 (8-14)

9 (8-11)

0.14

Preoperative parameters

 White blood cell (×  109/L)

3.39 (2.28-4.91)

3.61 (2.26-5.33)

0.53

 Neutrophils (× 109/L)

2.28 (1.46-3.51)

2.43 (1.58-3.62)

0.57

 Lymphocyte (× 109/L)

0.67 (0.40-1.03)

0.65 (0.47, 1.11)

0.44

 Red blood cell (×  1012/L)

2.97 (2.48-3.56)

3.01 (2.56-3.66)

0.57

 Hemoglobin (g/L)

91 (76-111)

92 (78-112)

0.63

 Platelet (× 109/L)

65 (40-105)

67 (41-109)

0.94

 Total protein (g/L)

59.00 (55.00-62.93)

59.62 (54.21-64.80)

0.56

 Albumin (g/L)

35.32 (32.57-39.40)

36.20 (32.20-39.02)

0.97

 TBIL (μmol/L)

35.91 (21.70-105.80)

37.27 (20.66-77.07)

0.33

 DBIL (μmol/L)

16.00 (9.29-51.61)

14.40 (9.03-32.81)

0.40

 IBIL (μmol/L)

18.88 (11.80-52.62)

18.54 (11.10-38.70)

0.31

 ALT (U/L)

26.00 (17.00-49.00)

27.50 (18.00-53.00)

0.39

 AST (U/L)

38.00 (25.00-66.00)

36.50 (26.00-68.00)

0.76

 LDH (U/L)

159.00 (133.00-193.00)

158.00 (139.00-202.00)

0.53

 BUN (mmol/L)

4.36 (3.56-5.44)

4.22 (3.41-5.73)

0.45

 sCr (μmol/L)

60.00 (48.00-74.00)

65.00 (54.00-78.00)

0.01

 UA (μmol/L)

231.00 (179.00-293.00)

247.00 (176.00-314.00)

0.29

 eGFR (mL/min/1.73 m2)

126.44 (99.21-160.67)

111.75 (94.99, 142.60)

0.02

Postoperative parameters

 Peak AST (U/L)

1239 (636-2325)

991 (679-1774)

0.27

 Postoperative RRT (N,%)

5 (4.7%)

16 (5.5%)

1.00

 Postoperative hospital stay (day)

24 (20, 29)

25 (21, 32)

0.12

 Length of ICU stay (day)

4 (3-5)

4 (3-5)

0.59

 AKI

71 (67.0%)

213 (72.7%)

0.26

 CKD

78 (26.6%)

29 (27.4%)

0.90

  1. Continuous variables are displayed as median and interquartile ranges
  2. Abbreviations: BMI Body mass index, MAP Mean arterial pressure, LVEF Left ventricular ejection fraction, MELD Model for End-Stage Liver Disease, TBIL Serum total bilirubin, DBIL Serum direct bilirubin, IBIL Serum indirect bilirubin, ALT Alanine aminotransferase, AST Aspartate aminotransferase, LDH Lactate dehydrogenase, BUN Blood urea nitrogen, sCr Serum creatinine, UA Uric acid, eGFR Estimated glomerular filtration rate, Peak AST AST peak value within first 24 h after OLT