From: Association between bone mineral metabolism and vascular calcification in end-stage renal disease
No. of patients | .32 |
---|---|
Female sex (%) | 13 (41) |
Age, y (median, range) | 66 (37-83) |
BMI (mean, SD) | 24 (3.7) |
Smoker (%) | 7 (22) |
History of diabetes (%) | 12 (38) |
History of cardiovascular disease (%) | 19 (59) |
History of myocardial infarction (%) | 6 (19) |
Dialysis vintage, month (median, IQR) | 10 (6 - 30) |
Dialysis modality (PD/HD) (%) | 50/50 |
Cause of ESRD | |
Diabetic nephropathy (%) | 11 (34) |
Hypertension/Arteriosclerosis (%) | 4 (13) |
Polycystic kidney disease (%) | 7 (22) |
Glomerulonephritis (%) | 6 (19) |
Other/unknown (%) | 4 (13) |
Laboratory parameters | |
fS-calcium-ion 1.16 mmol/l - 1.30 mmol/l (mean, SD)) | 1.17 (0.08) |
fP-phosphorus 0.71 – 1.23 mmol/l (median, IQR) | 1.68 (0.48) |
fP-iPTH 15 – 65 ng/l (median, IQR) | 319 (188 – 508) |
P- D-25 > 50 nmol/l (median, IQR) | 70 (49 – 95) |
S- D- 1,25 37 – 216 pmol/l (median, IQR) | 31 (24 – 52) |
P-tALP 35 – 105 U/l (median, IQR) | 84 (57 – 128) |
P-Albumine 36 – 45 g/l (median, IQR) | 32 (28 – 34) |
P-Magnesium 0.7 – 1 mmol/l (median, IQR) | 0.9 (0.7 – 1.0) |
cB-HCO3 22 – 26 mmol/l (median, IQR) | 24 (22 – 26) |
Bone histomorphometry | |
High turnover/hyperparathyreoid bone disease (%) | 11 (39) |
Normal turnover/mild hyperparathyroid bone disease (%) | 11 (39) |
Low turnover/adynamic bone disease (%) | 6 (22) |
Dynamic 18F-NaF PET | |
Lumbar spine, Ki mean L1-L4 (median, range) | 0.040 (0.023 – 0.093) |
Anterior iliac creast, FURmean hip (median, range) | 0.041 (0.025 – 0.081) |
DXA BMD T-score | |
T-score L1-L4 (mean, SD) | −1.06 (1.58) |
T-score femoral neck (mean, SD) | −2.0 (1.0) |
Osteoporosis (T-score ≤ −2.5) (%) | 10 (33) |
AAC score (median, range) | 8 (0 - 17) |
CAC score (median, range) | 397 (0 – 1980) |
Medication | |
Calcimimetic (%) | 5 (16) |
Alfacalcidol, Paricalcitol (%) | 21 (66) |
Calcium carbonate (%) | 28 (88) |
Cholecalciferol (%) | 29 (91) |
Sevelamer/lantane carbonate (%) | 18 (56) |
Corticosteroid (%) | 2 (6) |