From: Graft function and pregnancy outcomes after kidney transplantation
Course of kidney disease and pregnancy of the mothers: | |
 Duration of dialysis (yrs) | 2.85 ± 2.37 (0–9) |
 Preemptive transplantation (%) | n = 4 (5.97) |
 Living-transplant (%) | n = 23 (34.33) |
 Transplantation before the age of 18 years (%) | n = 14 (20.9) |
 Age of the mothers at transplantation (yrs) | 23.72 ± 7.18 (6.5–35) |
 Post-transplant hypertension pre-pregnancy (%) | n = 52/71 (73) |
 Age of the mothers at conception (yrs) | 29.6 ± 4.7 (15–39) |
 Time from transplantation to conception (yrs) | 6.51 ± 5.33 (0.5–24.75) |
 Transplant age at conception including donor age (yrs) | 39.75 ± 14.6 (9.5–67.2) |
Number of transplants: | |
 Pregnancy with the 1st transplant (%) | n = 82 (89.13) 85 deliveries (twins 3) |
 Pregnancy with the 2nd transplant (%) | n = 10 (10.87) 10 deliveries |
 re-Tx once after that with pregnancy (%) | n = 11 (11.96) |
 re-Tx twice after that with pregnancy (%) | n = 4 (4.35) |
Additional extrarenal transplants: | |
 Combined pancreas-kidney-transplantation | n = 3a |
 Liver before kidney transplantation | n = 2 |
Timing of pregnancy after transplantation: | |
 Pregnancy in yr 1–5 after transplantation (%) | n = 44 (47.83) |
 Pregnancy in yr 6–10 after transplantation (%) | n = 28 (30.43) |
 Pregnancy in yr 11–20 after transplantation (%) | n = 17 (18.48) |
 Pregnancy beyond yr 20 after transplantation (%) | n = 3 (3.26) |
Number of pregnancies and deliveries per woman beyond the first trimester: | |
 1 Pregnancy (%) | n = 46 (50) 48 deliveries (twins 2) |
 2 Pregnancies (%) | n = 18 (39.13) 37 deliveries (twins 1) |
 3 Pregnancies (%) | n = 2 (6.52) 6 deliveries |
 4 Pregnancies (%) | n = 1 (4.35) 4 deliveries |
Immunosuppression during pregnancy | |
 Azathioprin, prednisolone (%) | n = 11 (11.96) |
 Cyclosporine, prednisolone (%) | n = 40 (43.48) |
 Cyclosporine, azathioprine, prednisolone (%) | n = 12 (13.04) |
 Tacrolimus, prednisolone (%) | n = 11 (11.96) |
 Tacrolimus, azathioprine, prednisolone (%) | n = 18 (19.57) |
Mean pre-pregnancy eGFR: | |
 All pregnancies | 59.39 ± 17.62 mL/min (n = 88) |
 Pre-pregnancy eGFR ≥ 60 mL/min/1.73m2 | 73.91 ± 10.33 (n = 44) |
 Pre-pregnancy eGFR ≥ 50-60 mL/min/1.73m2 | 54.16 ± 3.95 (n = 16) |
 Pre-pregnancy eGFR ≥ 40-50 mL/min/1.73m2 | 45.79 ± 3.36 (n = 14) |
 Pre-pregnancy eGFR < 40 mL/min/1.73m2 | 33.33 ± 4.29 (n = 14) |
Fetal outcome: | |
 gestational age at birth (weeks) | 34.44 ± 5.02 weeks (n = 88) |
 live-birthrate | n = 86 (90.53%) |
   < 37 SSW | n = 45 (von 76) |
  < 34 SSW | n = 20 (von 76) |
   < 28 SSW | n = 2 (von 76) |
 Cesarian section (%) | n = 67 von 88 (76.1) |
 Mean birth weight | 2146.75 ± 926.14 (n = 82) |
 Mean birth weight (only live birth) | 2322.26 ± 781.98 (n = 79) |
   ≤ 2500 | n = 40 (of 79) |
   ≤ 1500 | n = 21 (of 79) |
   ≤ 1000 | n = 6 (of 79) |