Left ventricular mass regression, all-cause and cardiovascular mortality in chronic kidney disease: a meta-analysis

Table 3 Sensitivity analyses for the pooled relative risk of all-cause mortality in patients with chronic kidney disease using different minimum follow-up thresholds for studies in which left ventricular mass was reduced in the intervention group relative to the control group and there was ≥1 event in ≥1 group^a

Follow-up	Number of Trials	Intervention, Events/n	Control, Events/n	Pooled RR^b	95% CI
≥6 Months	34	135/2541	177/2560	0.74	0.59 to 0.92
≥9 Months	29	121/2210	171/2302	0.71	0.57 to 0.90
≥12 Months	27	121/2151	168/2216	0.72	0.57 to 0.90
>12 Months	10	40/865	78/938	0.53	0.37 to 0.77

CI confidence interval, RR relative risk
^aPooled estimates are from random effects analysis. The category of ≥12 months of follow-up is shown in bold because it was the prespecified primary minimum follow-up threshold. Median reductions in LVM in the intervention groups compared with the control groups were − 0.23, −0.25, −0.26 and − 0.28 standardized mean differences in the categories of, ≥6, ≥9, ≥12 and > 12 months, respectively
^bP-_{heterogeneity} = 0.923 for ≥6 months, 0.898 for ≥9 months, 0.851 for ≥12 months, and 0.971 for >12 months

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