Serum chromogranin A correlated with albuminuria in diabetic patients and is associated with early diabetic nephropathy

Table 2 Correlation between serum CgA and clinical and laboratory data of subjects

Clinical and laboratory data	CgA (in all subjects) (n = 264)		CgA (in patients with T2DM) (n = 219)
Clinical and laboratory data	r	P	r	P
Known diabetes duration (years)	0.302	< 0.001	0.171	0.011
Age (years)	0.066	0.286	0.053	0.434
SBP (mmHg)	0.099	0.110	−0.029	0.673
DBP (mmHg)	−0.084	0.172	−0.170	0.012
FBG (mmol/L)	0.240	< 0.001	0.128	0.060
HbA1c (%)	0.285	< 0.001	0.144	0.033
UACR (mg/g)	0.441	< 0.001	0.408	< 0.001
sCr (umol/L)	0.163	0.008	0.188	0.005
BUN (mmol/L)	0.229	< 0.001	0.202	0.003
sUA (ummol/L)	0.061	0.322	0.049	0.470
eGFR (ml/min/1.73 m²)	−0.227	< 0.001	−0.252	< 0.001
TC (mmol/L)	−0.118	0.056	−0.109	0.107
TG (mmol/L)	0.035	0.572	−0.049	0.473
LDL-C (mmol/L)	−0.109	0.076	−0.105	0.120
HDL-C (mmol/L)	−0.124	0.044	−0.027	0.689

SBP systolic blood pressure, DBP diastolic blood pressure, FBG fasting blood glucose, HbA1c hemoglobin A1c, UACR urine albumin to creatinine ratio, sCr serum creatinine, BUN blood urea nitrogen, sUA serum uric acid, eGFR estimated glomerular filtration rate, TC total cholesterol, TG triglyceride, LDL-C low density lipoprotein cholesterol, HDL-C high density lipoprotein cholesterol, CgA Chromogranin A

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