Table 2 Kidney pathological findings in the 12 patients from the present cohort
From: Biopsy-proven kidney involvement in hypocomplementemic urticarial vasculitis
Patient 1 | Patient 2 (2003) | Patient 2 (2008) | Patient 3 | Patient 4 | Patient 5 | Patient 6 | Patient 7 (2012) | Patient 7 (2016) | Patient 8 | Patient 9 (2018) | Patient 9 (2021) | Patient 10 | Patient 11 | Patient 12 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pathological diagnosis | MPGN | MPGN | MPGN | MPGN | MPGN | MPGN | MPGN | MPGN | MPGN | MPGN | Pauci-immune CGN | Advanced chronic lesions | Pauci-immune CGN | Necrotizing vasculitis | Interstitial nephritis |
Number of glomeruli | 21 | 7 | 13 | 12 | 22 | 11 | 45 | 13 | 16 | 9 | 21 | 18 | 22 | 10 | 14 |
Endocapillary hypercellularity | severe | mild | mild | mild | moderate | mild | moderate | mild | mild | moderate | – | – | – | – | – |
Crescents (% of glomeruli) | 30 | 15 | – | – | 15 | – | 10 | – | 5 | – | 40 | – | 15 | – | – |
Glomerular sclerosis (%) | 30 | – | 30 | – | – | – | – | 60 | 60 | – | 15 | > 90 | 20 | – | 15 |
Subendothelial deposits | IgG+++ C3+/− | IgG+ IgM+/− C3+/− C1q+ | IgG+ C3+ | IgG++ IgM++ C3+++ C4++ C1q+++ | IgG+ IgM+ C3++ C4+ C1q++ | IgA+ IgG+ IgM+ C1q + | IgG++ C3+++ | IgG+ IgM+ C3+++ C1q++ | IgM++ C3++ C1q+ | IgA+ IgG++ IgM+/− C3+/− C1q +/− | IgA+ | – | – | – | – |
Micro thrombi | + | – | – | + | + | – | – | – | – | – | – | – | – | – | – |
Interstitial inflammation | severe | severe | mild | severe | mild | mild | mild | severe | severe | moderate | moderate | – | moderate | severe | moderate |
Interstitial fibrosis | mild | – | moderate | – | – | mild | – | severe | severe | moderate | moderate | severe | mild | – | mild |
Tubular immune deposits | – | IgG+ C1q+ | – | – | C1q++ | – | – | – | – | IgG++ | IgG+++ IgM+ C3+ C1q+ | IgA + IgG+++ IgM+ C3+ | – | – | IgG+/− C1q+/− |
Necroziting vasculitis | – | + | – | – | – | – | – | – | – | – | – | – | – | ++ | – |
Chronic vascular lesions | – | + | + | – | + | + | – | + | + | + | + | + | + | + | + |
Vascular Immune deposits | – | IgG+++ IgM+ C3+ C1q++ | IgG++ IgM++ C3+ C1q+ | – | C1q+ | – | – | – | – | – | IgG+++ IgM+ C3+ C1q+ | IgA + IgG+++ IgM+ C3+ | C3+ | C3+/− | C3+ |