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Table 4 Other indicators before and after intervention

From: Efficacy and safety of a low-sodium diet and spironolactone in patients with stage 1-3a chronic kidney disease: a pilot study

Parameters

Low-sodium+placebo (n = 27)

Medium-sodium+SPL (n = 24)

Low-sodium+SPL (n = 23)

P

ALB (g/L)

Before Intervention

43.66 ± 2.26

42.78 ± 2.71

42.77 ± 2.64

0.356

After Intervention

42.60 ± 2.75

43.07 ± 1.97

43.12 ± 2.79

0.725

P

0.018

0.677

0.401

 

PA (g/L)

Before Intervention

0.33 ± 0.07

0.34 ± 0.06

0.35 ± 0.09

0.622

After Intervention

0.33 ± 0.06

0.33 ± 0.06

0.35 ± 0.08

0.317

P

0.824

0.214

0.843

 

eDPI (g/kg/d)

Before Intervention

1.06 ± 0.21

1.00 ± 0.26

1.08 ± 0.23

0.465

After Intervention

1.02 ± 0.25

1.05 ± 0.16

1.09 ± 0.17

0.385

P

0.377

0.413

0.770

 

Scr (μmol/L)

Before Intervention

81.66 ± 28.61

76.42 ± 30.90

83.43 ± 28.73

0.694

After Intervention

77.68 ± 23.50

77.42 ± 29.20

83.96 ± 30.40

0.655

P

0.020

0.696

0.780

 

BUN (mmol/L)

Before Intervention

6.02 ± 1.62

5.66 ± 1.82

5.78 ± 2.03

0.767

After Intervention

5.73 ± 2.07

5.97 ± 1.30

6.21 ± 2.20

0.666

P

0.206

0.315

0.055

 

UA (μmol/L)

Before Intervention

374.90 ± 75.84

360.29 ± 83.86

378.09 ± 75.51

0.705

After Intervention

374.38 ± 82.16

385.08 ± 76.40

365.13 ± 88.35

0.709

P

0.964

0.159

0.457

 

TC (mmol/L)

Before Intervention

4.57 ± 0.86

4.56 ± 1.07

4.54 ± 0.77

0.993

After Intervention

4.15 ± 0.73

4.68 ± 0.95

4.50 ± 0.93

0.092

P

0.001

0.668

0.824

 

TG (mmol/L)

Before Intervention

1.38 ± 0.62

2.30 ± 2.06

1.75 ± 0.90

0.053

After Intervention

1.25 ± 0.60

1.68 ± 0.94

1.72 ± 0.76

0.060

P

0.201

0.068

0.852

 

LDL-C (mmol/L)

Before Intervention

2.57 ± 0.56

2.83 ± 0.78

2.76 ± 0.70

0.364

After Intervention

2.19 ± 0.59a)、b)

2.82 ± 0.75

2.59 ± 0.71

0.006

P

0.001

0.881

0.249

 

CRP (mg/L)

Before Intervention

1.76 ± 1.98

1.26 ± 1.01

1.51 ± 1.56

0.547

After Intervention

1.54 ± 1.86

1.42 ± 1.15

1.67 ± 2.30

0.890

P

0.588

0.564

0.613

 

SBP (mmHg)

Before Intervention

118.15 ± 9.81

119.29 ± 11.51

122.30 ± 11.85

0.403

After Intervention

116.52 ± 9.69

113.46 ± 11.98

117.65 ± 9.73

0.367

P

0.413

0.003

0.086

 

DBP (mmHg)

Before Intervention

72.30 ± 7.31

72.88 ± 9.13

72.87 ± 10.46

0.965

After Intervention

71.52 ± 7.76

69.42 ± 8.12

70.39 ± 9.17

0.668

P

0.582

0.029

0.209

 
  1. a) P < 0.05, compared with medium-sodium (5 g/d salt) + SPL
  2. b) P < 0.05, compared with low-sodium (3 g/d salt) + SPL
  3. Data are mean ± standard deviation. ALB albumin, PA pre-albumin, eDPI estimated daily protein intake, Scr serum creatinine, BUN blood urea nitrogen, UA uric acid, CRP C-reactive protein, SBP systolic blood pressure, DBP diastolic blood pressure
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BMC Nephrology

ISSN: 1471-2369

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