Table 2 Renal and cardiac mRNA expression of SARS-CoV-2 host factors and genes involved in RAAS

mRNA expression (kidney)

  Ace2

1.02 ± 0.09

1.19 ± 0.30

1.01 ± 0.33

1.14 ± 0.14

1.47 ± 0.47

1.33 ± 0.33

  Tmprss2

1.03 ± 0.12

0.50 ± 0.09

0.86 ± 0.09

2.11 ± 0.41^b

0.97 ± 0.08

4.23 ± 2.92^b

  Ren

1.06 ± 0.18

0.06 ± 0.02^ab

0.06 ± 0.04^a

1.56 ± 0.56^b

0.12 ± 0.03^a

2.52 ± 1.17^b

  Agtr2

1.03 ± 0.13

0.78 ± 0.21

1.08 ± 0.19

1.02 ± 0.13

0.84 ± 0.16

3.09 ± 1.41

  Agt

1.10 ± 0.24

1.13 ± 0.28

1.02 ± 0.24

1.63 ± 0.29

1.57 ± 0.17

4.32 ± 1.67

mRNA expression (heart)

  Ace2

1.04 ± 0.19

0.94 ± 0.06

1.17 ± 0.08

1.08 ± 0.08

0.77 ± 0.06

1.03 ± 0.08

  Tmprss2

n.d

n.d

n.d

n.d

n.d

n.d

  Ren

n.d

n.d

n.d

n.d

n.d

n.d

  Agtr2

1.01 ± 0.06

1.06 ± 0.07

1.13 ± 0.09

0.98 ± 0.06

0.91 ± 0.09

0.97 ± 0.5

  Agt

1.04 ± 0.12

1.79 ± 0.23

0.95 ± 0.04

1.19 ± 0.20

0.77 ± 0.09

0.92 ± 0.07

Sham + ND + PBO (n = 12–14)

5/6Nx + ND + PBO (n = 7–12)

5/6Nx + HSD + PBO (n = 15–20)

5/6Nx + HSD + TELM (n = 7–11)

5/6Nx + HSD + LINA (n = 10–13)

5/6Nx + HSD + EMPA (n = 6–9)

protein expression

  ACE2 (kidney)

29.89

27.10

13.96

14.14

33.25

17.07

(20.82–36.55)

(19.39–30.73)

(12.36–19.14)^a

(9.35–19.34)^a

(18.55–39.25)^b

(12.59–19.96)

  ACE2 (heart)

27.77

33.11

29.12

27.42

24.39

33.21

(25.58–32.96)

(30.74–36.34)

(23.97–32.42)

(24.57–31.01)

(22.32–29.63)

(26.57–35.92)

  TMPRSS2 (kidney)

13.44

13.88

12.77

12.35

12.21

11.60

(11.64–17.31)

(11.89–15.73)

(8.53–14.21)

(10.79–18.26)

(9.72–13.90)

(10.62–13.29)

  TMPRSS2 (heart)

11.90

29.57

25.23

10.40

7.85

12.00

(10.63–15.00)

(25.12–33.16)^a

(16.18–30.46)^a

(8.60–18.57)^b

(6.03–13.39)^b

(8.59–16.27)^b