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Fig. 4 | BMC Nephrology

Fig. 4

From: METTL3 enhances NSD2 mRNA stability to reduce renal impairment and interstitial fibrosis in mice with diabetic nephropathy

Fig. 4

METTL3 promotes NSD2 expression. A m6A modification level in HG-induced SV40-MES-13 cells; B m6A modification on NSD2 mRNA in HG-induced SV40-MES-13 cells; C expression of METTL3 mRNA in patients with DN and healthy individuals examined by RT-qPCR; D A positive correlation between serum NSD2 and METTL3 levels in patients with DN; E Transfection efficacy of vector-METTL3 examined by RT-qPCR; F-G, mRNA (F) and protein (G) expression of NSD2 in cells after METTL3 overexpression determined by RT-qPCR and western blot analysis. Data were expressed as the mean ± SD from three independent experiments. Differences were analyzed by the unpaired t test (A, B, C, E, F and G). In panel D, correlation between NSD2 and METTL3 levels was analyzed by Pearson’s correlation analysis. *p < 0.05

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BMC Nephrology

ISSN: 1471-2369

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