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Table 3 Cox Proportional Hazards Models for patient all-cause mortality and ESKD divided by DM and hyperuricemia

From: Hyperuricemia and diabetes mellitus when occurred together have higher risks than alone on all-cause mortality and end-stage renal disease in patients with chronic kidney disease

 

No. of Events

Univariate

95% CI

p-value

Multivariate 95% CIa

p-value

All-cause mortality

 Neither DM nor Hyperuricemia

49

REF.

 

REF.

–

 Hyperuricemia only

142

1.46(1.05–2.02)

0.0228

1.48(1–2.19)

0.0493

 DM only

48

1.59(1.07–2.36)

0.023

1.52(1.02–2.46)

0.0088

 Both DM and Hyperuricemia

117

2.13(1.53–2.98)

<.0001

2.12(1.41–3.19)

0.0003

ESKD

 Neither DM nor Hyperuricemia

121

REF.

 

REF.

–

 Hyperuricemia only

388

1.72 (1.40–2.10)

<.0001

1.34(1.03–1.73)

0.0271

 DM only

107

1.48 (1.14–1.92)

0.003

1.59(1.15–2.2)

0.0055

 Both DM and  Hyperuricemia

316

2.61 (2.11–3.22)

<.0001

2.46(1.87–3.22)

<.0001

Dialysis with considering competing risk of mortality

 Neither DM nor Hyperuricemia

121

REF.

 

REF.

 

 Hyperuricemia only

388

1.671(1.366–2.044)

<.0001

1.266(0.97–1.651)

0.0825

 DM only

107

1.428(1.106–1.844)

0.0064

1.529(1.064–2.197)

0.0218

 Both DM and Hyperuricemia

316

2.467(2.004–3.036)

<.0001

2.251(1.702–2.978)

<.0001

  1. Note: adjusted for age, sex, ever smoke, previous CAD, 1 year mean SBP, use of statin, hyperuricemia drug usage, ACEi/ARB usage