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Table 3 Odds ratios for new-onset chronic kidney disease according to baseline serum leptin level

From: Serum leptin level and incidence of CKD: a longitudinal study of adult enrolled in the Korean genome and epidemiology study(KoGES)

Serum leptin level   Odds ratio (95% CI)
Tertile 1 Tertile 2 Tertile 3 Odds ratio for trend P for trend
All (n = 2646)
 Serum leptin (ng/L)  < 3.09 3.09 – 7.23  ≥ 7.23   
 No. of new-onset CKD 14 26 28   
 Crude Reference 1.88 (0.98 – 3.63) 1.97 (1.03 – 3.76) 1.36 (1.00 – 1.83) 0.048
 Model 1 Reference 2.25 (1.16 – 4.37) 2.44 (1.27 – 4.71) 1.50 (1.11 – 2.03) 0.009
 Model 2 Reference 1.44 (0.74 – 2.82) 1.17 (0.60 – 2.28) 1.05 (0.77 – 1.43) 0.770
 Model 3 Reference 1.62 (0.83 – 3.19) 1.41 (0.72 – 2.78) 1.15 (0.34 – 1.57) 0.394
Men (n = 1100)
 Serum leptin (ng/L)  < 1.68 1.68 – 2.87  ≥ 2.87   
 No. of new-onset CKD 2 3 13   
 Crude Reference 1.50 (0.25 – 9.03) 6.46 (1.45 – 28.83) 2.95 (1.41 – 6.18) 0.004
 Model 1 Reference 1.76 (0.29 – 10.68) 7.91 (1.75 – 35.64) 3.19 (1.53 – 6.68) 0.037
 Model 2 Reference 1.17 (0.19 – 7.21) 3.53 (0.76 – 16.30) 2.13 (1.00 – 4.53) 0.049
 Model 3 Reference 1.14 (0.18 – 7.12) 3.81 (0.82 – 17.77) 2.25 (1.05 – 4.85) 0.037
Women (n = 1546)
 Serum leptin (ng/L)  < 6.07 6.07 – 9.77  ≥ 9.77   
 No. of new-onset CKD 17 13 20   
 Crude Reference 0.76 (0.37 – 1.58) 1.14 (0.59 – 2.21) 1.08 (0.76 – 1.52) 0.667
 Model 1 Reference 0.80 (0.38- 1.68) 1.22 (0.63 – 2.37) 1.11 (0.79 – 1.57) 0.550
 Model 2 Reference 0.70 (0.33 – 1.46) 0.91 (0.47 – 1.80) 0.96 (0.68 – 1.37) 0.829
 Model 3 Reference 0.73 (0.34 – 1.53) 0.97 (0.49 – 1.91) 0.99 ()0.70 – 1.41) 0.967
Model 1: adjusted for age
Model 2: adjusted for baseline eGFR
Model 3: adjusted for age and baseline eGFR