Table 3 Odds ratios for new-onset chronic kidney disease according to baseline serum leptin level
Serum leptin level | Odds ratio (95% CI) | ||||
|---|---|---|---|---|---|
Tertile 1 | Tertile 2 | Tertile 3 | Odds ratio for trend | P for trend | |
All (n = 2646) | |||||
Serum leptin (ng/L) | < 3.09 | 3.09 – 7.23 | ≥ 7.23 | ||
No. of new-onset CKD | 14 | 26 | 28 | ||
Crude | Reference | 1.88 (0.98 – 3.63) | 1.97 (1.03 – 3.76) | 1.36 (1.00 – 1.83) | 0.048 |
Model 1 | Reference | 2.25 (1.16 – 4.37) | 2.44 (1.27 – 4.71) | 1.50 (1.11 – 2.03) | 0.009 |
Model 2 | Reference | 1.44 (0.74 – 2.82) | 1.17 (0.60 – 2.28) | 1.05 (0.77 – 1.43) | 0.770 |
Model 3 | Reference | 1.62 (0.83 – 3.19) | 1.41 (0.72 – 2.78) | 1.15 (0.34 – 1.57) | 0.394 |
Men (n = 1100) | |||||
Serum leptin (ng/L) | < 1.68 | 1.68 – 2.87 | ≥ 2.87 | ||
No. of new-onset CKD | 2 | 3 | 13 | ||
Crude | Reference | 1.50 (0.25 – 9.03) | 6.46 (1.45 – 28.83) | 2.95 (1.41 – 6.18) | 0.004 |
Model 1 | Reference | 1.76 (0.29 – 10.68) | 7.91 (1.75 – 35.64) | 3.19 (1.53 – 6.68) | 0.037 |
Model 2 | Reference | 1.17 (0.19 – 7.21) | 3.53 (0.76 – 16.30) | 2.13 (1.00 – 4.53) | 0.049 |
Model 3 | Reference | 1.14 (0.18 – 7.12) | 3.81 (0.82 – 17.77) | 2.25 (1.05 – 4.85) | 0.037 |
Women (n = 1546) | |||||
Serum leptin (ng/L) | < 6.07 | 6.07 – 9.77 | ≥ 9.77 | ||
No. of new-onset CKD | 17 | 13 | 20 | ||
Crude | Reference | 0.76 (0.37 – 1.58) | 1.14 (0.59 – 2.21) | 1.08 (0.76 – 1.52) | 0.667 |
Model 1 | Reference | 0.80 (0.38- 1.68) | 1.22 (0.63 – 2.37) | 1.11 (0.79 – 1.57) | 0.550 |
Model 2 | Reference | 0.70 (0.33 – 1.46) | 0.91 (0.47 – 1.80) | 0.96 (0.68 – 1.37) | 0.829 |
Model 3 | Reference | 0.73 (0.34 – 1.53) | 0.97 (0.49 – 1.91) | 0.99 ()0.70 – 1.41) | 0.967 |
Model 1: adjusted for age Model 2: adjusted for baseline eGFR Model 3: adjusted for age and baseline eGFR | |||||