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Table 2 Risk of malignancies in kidney transplantation recipients

From: Risk of malignancy in kidney transplant recipients: a nationwide population-based cohort study

Malignancy site

Univariable analysis

Multivariable analysis

Crude RR (95% CI)

P

Adjusted RR (95% CI)

P

Head and neck

3.8 (1.7–8.7)

0.002

3.6 (1.5–9.1)

0.006

Lip

1.1 (0.1–12.5)

0.926

3.9 (0.3–50.0)

0.295

Digestive

 Esophagus

1.6 (0.5–4.9)

0.391

1.7 (0.5–6.6)

0.415

 Stomach

1.7 (1.3–2.2)

 < 0.001

1.7 (1.3–2.3)

 < 0.001

 Colon and rectum

1.0 (0.7–1.3)

0.893

1.0 (0.7–1.3)

0.776

 Anus

8.9 (0.2–365.2)

0.250

16.4 (0.4–682.9)

0.142

 Liver

1.8 (1.3–22.5)

0.001

1.3 (0.9–1.8)

0.224

 Gallbladder and bile duct

1.6 (0.8–3.2)

0.189

2.5 (1.2–5.5)

0.021

 Pancreas

2.3 (1.2–4.2)

0.011

2.1 (1.1–4.3)

0.032

 Lung

1.8 (1.3–2.5)

 < 0.001

1.6 (1.1–2.4)

0.010

 Bone and cartilage

1.4 (0.2–10.4)

0.735

4.3 (0.2–95.3)

0.356

 Melanoma

2.3 (0.4–11.9)

0.321

0.9 (0.1–5.8)

0.919

 Non-melanoma skin cancera

5.2 (2.9–9.4)

 < 0.001

3.7 (2.0–7.2)

 < 0.001

 Kaposi’s sarcoma

32.1 (1.7–588.4)

0.020

23.6 (1.3–416.8)

0.031

 Breast

1.4 (1.0–1.9)

0.078

2.3 (1.5–3.5)

 < 0.001

 Uterine cervix

0.5 (0.2–1.1)

0.090

0.7 (0.3–1.6)

0.375

 Uterus

2.6 (1.0–6.6)

0.053

7.5 (2.0–27.6)

0.003

 Ovary

0.9 (0.4–1.8)

0.673

1.9 (0.8–4.8)

0.154

 Vulva, vagina

0.3 (0.0–14.7)

0.568

0.5 (0.0–41.1)

0.742

 Prostate

1.3 (0.9–1.9)

0.154

1.0 (0.6–1.5)

0.892

 Testis

4.1 (0.5–36.8)

0.207

2.8 (0.3–28.2)

0.377

Urinary tract

 Kidney

14.8 (7.9–27.4)

 < 0.001

14.9 (7.9–28.3)

 < 0.001

 Bladder/urinary tract

4.4 (2.6–7.5)

 < 0.001

4.1 (2.3–7.3)

 < 0.001

 Brain

1.0 (0.4–2.3)

0.943

1.3 (0.5–3.2)

0.620

 Thyroid

1.4 (1.1–1.8)

0.007

2.2 (1.6–3.0)

 < 0.001

Hematopoietic system

 Hodgkin’s lymphoma

1.4 (0.2–9.9)

0.761

2.7 (0.3–22.5)

0.348

 NHL

3.4 (2.2–5.1)

 < 0.001

4.2 (2.7–6.6)

 < 0.001

 Multiple myeloma

2.8 (0.9–9.3)

0.087

1.6 (0.4–6.2)

0.491

 Leukemia

1.1 (0.5–2.4)

0.824

0.7 (0.3–1.8)

0.514

 Unknown primary

2.6 (1.5–4.4)

 < 0.001

2.4 (1.4–4.4)

0.003

 Total

1.9 (1.7–2.1)

 < 0.001

1.8 (1.6–2.0)

 < 0.001

  1. KT kidney transplantation, CI confidence interval, RR relative risk, NHL Non–Hodgkin’s lymphoma
  2. The relative risk was obtained from the Cox model adjusted for age, sex, and the presence or absence of any of investigated comorbidities as in Table 1
  3. aNon-melanoma skin cancer is a composite of Merkel, squamous, and basal cell carcinomas
  4. bCancers of the breast and female genital tracts were investigated only in females, whereas prostate and testicular cancers were analyzed only in males
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BMC Nephrology

ISSN: 1471-2369

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