Skip to main content

Table 2 Association of different PPIs with SIADH

From: Syndrome of inappropriate antidiuretic hormone secretion is associated with different proton pump inhibitor use: a pharmacovigilance study

Drug

N

ROR (95% CI)

PRR (χ2)

IC (IC025)

EBGM (EBGM05)

Omeprazole

122

9.7 (8.1, 11.6)a

9.6 (920.1)a

3.2 (2.7)a

9.4 (8.1)a

Lansoprazole

43

4.5 (3.3, 6.0)a

4.4 (113.9)a

2.1 (1.6)a

4.4 (3.4)a

Dexlansoprazole

0

0 (−)

0 (−)

0 (−)

0 (−)

Pantoprazole

64

6.9 (5.4, 8.9)a

6.9 (319.1)a

2.8 (2.2)a

6.8 (5.6)a

Rabeprazole

10

13.4 (7.2, 24.9)a

13.3 (113.7)a

3.7 (2.0)a

13.3 (7.9)a

Esomeprazole

34

0.6 (0.5, 0.9)

0.6 (7.6)

−0.7 (−)

0.6 (0.5)

  1. PPIs Proton pump inhibitors, SIADH Inappropriate secretion of antidiuretic hormone, CI Confidence interval, PRR Proportional reporting ratio, ROR Reported odds ratio, IC Information component, IC025 Lower limit of the 95% two-sided confidence interval for IC
  2. adenotes significant signals