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Table 2 Base case cost effectiveness of SZC versus usual care

From: Cost effectiveness of sodium zirconium cyclosilicate for the treatment of hyperkalaemia in patients with CKD in Norway and Sweden

 

Norway

Sweden

SZC

Usual care

Difference

SZC

Usual care

Difference

Total costs

85,421

82,332

3,089

65,805

62,735

3,070

 Treatment

13,767

90

13,677

10,490

44

10,446

 Adverse events

847

41

806

471

24

447

 Hyperkalaemia

9,270

22,371

-13,101

6,440

15,038

-8,598

 CKD

35,257

32,790

2,467

21,214

19,697

1,517

 RRTa

0

0

0

0

0

0

 Arrhythmia

1,448

1,395

53

1,149

1,105

44

 CV

5,063

4,996

67

6,524

6,348

176

 Hospitalisation

10,594

11,255

-660

16,741

17,753

-1,012

 RAASi use change

9,174

9,394

-220

2,775

2,725

50

Total LYs

4.840

4.501

0.339

4.966

4.611

0.354

Total QALYs

2.988

2.780

0.208

2.998

2.784

0.214

 QALYs

4.002

3.725

0.276

4.030

3.745

0.286

 Health state (CKD)

-0.712

-0.658

-0.054

-0.724

-0.668

-0.057

 Adverse events

-0.003

-0.003

0.000

-0.003

-0.003

0.0003

 Arrhythmia

-0.001

-0.001

0.000

-0.001

-0.001

0.0000

 CV

-0.294

-0.279

-0.014

-0.300

-0.285

-0.0154

 Hospitalisation

-0.004

-0.005

0.000

-0.005

-0.005

0.0003

Cost/LY

9,119

8,663

Cost/QALY (ICER)

14,838

14,352

  1. Threshold for initiating treatment for initial and recurrent hyperkalaemia events: serum K+ ≥ 5.5 mmol/L. All costs presented in Euros
  2. a In the base case, all patients exited the model before commencing RRT
  3. CKD Chronic kidney disease, CV Cardiovascular, ICER Incremental cost-effectiveness ratio, LY Life year, QALY Quality-adjusted life year, RAASi Renin–angiotensin–aldosterone system inhibitor, RRT Renal replacement therapy, SZC sodium zirconium cyclosilicate