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Table 1 Basal patient characteristics according to MELD era

From: Modelling kidney outcomes based on MELD eras - impact of MELD score in renal endpoints after liver transplantation

 

PRE-MELD ERA

POST MELD ERA

P value

 

N= 408

N=466

 

Age, years

52.5 [45.25; 60]

54 [45; 61]

0.11

Gender, male (%)

266 (65)

328 (70)

0.18

BMI (Kg/m2)

25.2 [22.6; 28]

25.95 [23.1; 29.8]

0.02

Hypertension (%)

31 (8)

139 (30)

 < 0.01

Diabetes (%)

79 (8)

139 (30)

0.02

APACHE 2

16 [13; 20]

17 [15; 18]

0.01

SAPS 3

39 [36; 42]

39 [28; 53]

0.83

Admission eGFR (mL/min/1.73m2)

91.5 [72; 110]

88 [57; 125]

0.46

Cause of liver disease

 Hepatitis C (%)

190 (47)

209 (45)

0.63

 Hepatitis B (%)

40 (10)

30 (6)

0.08

 Alcoholic liver cirrhosis (%)

83 (20)

92 (20)

0.87

 Others (%)

75(18)

122 (26)

0.01

Hepatocellular carcinoma (%)

94 (23)

180 (39)

 < 0.01

Familial amyloid polyneuropathy (%)

17 (4)

22 (5)

0.74

Pre-Transplant Albumin level (g/dL)

3.1 [2.7; 3.4]

3 [2.6; 3.4]

0.14

CPT Score

  

 < 0.01

  A or non-cirrhotic (%)

70 (17)

54 (12)

 

  B (%)

203 (50)

209 (45)

 

  C (%)

135 (33)

203 (44)

 

MELD score

14 [10; 18]

18 [11; 25]

 < 0.01

  Preoperative Creatinine (mg/dL)

0.9 [0.7; 1.07]

0.92 [0.7; 1.32]

0.01

  Preoperative Total bilirubin (mg/dL)

2.6 [1.7; 4.6]

3 [1.8; 7;5]

 < 0.01

  Preoperative prothrombin time, INR

1.6 [1.4; 1.96]

1.7 [1.35; 2.22]

0.14

Surgical aspects

 Deceased donor (%)

252 (62)

466 (100)

 < 0.01

 Piggyback technique (%)

389 (95.3)

464 (99.6)

 < 0.01

 Operation time (h)

7.55 [6.67; 8.5]

6 [5.17; 6.94]

 < 0.01

 Total ischemia time (h)

6.77 (2.70; 10.15]

9.08 [ 7.87; 10.67]

 < 0.01

 Vasopressor (%)

40 (9.8)

315 (67.6)

 < 0.01

 Number of blood packs

4 [2; 8]

3 [2; 7]

0.18

Post-transplant care

 Sepsis during hospitalization (%)

157 (39)

158 (34)

0.18

 Vasopressor after transplant (%)

70 (17)

264 (30)

 < 0.01

 Tacrolimus based immunosuppression (%)

299 (73)

459 (98.5)

 < 0.01

 First week Tacrolimus peak level (ng/mL)

12.6 [9.9; 15.9]

5.7 [3.9; 7.5]

 < 0.01

 Acute liver rejection (%)

123 (30)

69 (15)

 < 0.01

 Nephrotoxic exposure (%)

285 (70)

152 (30)

 < 0,01

 Urinary output (ml/Kg/H)

0.25 [0.15; 0.37]

0.55 [0.35; 0.83]

 < 0.01

  1. Data are expressed as median [IQR] or percentage
  2. BMI Body mass index, APACHE 2 Acute Physiology and Chronic Health Evaluation II, SAPS 3 Simplified Acute Physiology Score III, eGFR Estimated Glomerular filtration rate, MELD Model for End-Stage Liver Disease, CPT Child–Pugh-Turcote, ICU Intensive Care Unit
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BMC Nephrology

ISSN: 1471-2369

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