Fig. 1

Tuberculosis manifestation A-B: Bioptic samples from the stenotic region of the large bowel (A) and from the duodenum (B). A: The architecture of the mucosa is impaired, and the crypts are distorted and cystically dilated. In the lamina propria, there is a severe chronic active inflammation with crypt abscess and ulceration. In deeper parts of the bowel mucosa and submucosa, there is a vaguely formed collection of epithelioid macrophages surrounded by a chronic inflammatory infiltrate (haematoxylin and eosin, magnification 100x); B: In the lamina propria, there is a collection of foamy macrophages strongly positive in the periodic acid-Shiff stain. The rest of the mucosa is devoid of any inflammation and the architecture is intact (periodic acid-Shiff, 200x); C-D: Repeated biopsy after two-months internal. Bioptic samples from the inflamed colonic mucosa (C) and terminal ileum (D). C: There is chronic active colitis with largely preserved mucosal architecture. The activity of the inflammation is superficially localized, with neutrophils infiltrating surface epithelium. In the centre of the picture, there is a small mucosal defect with incipient exudation of fibrin (haematoxylin and eosin, 200x); D: In the centre of the picture, there is an isolated mucosal collection of epithelioid macrophages (epithelioid microgranuloma). The surrounding mucosa is slightly oedematous and hyperaemic (haematoxylin and eosin, 200x); E: Circular stenosis above Bauhin’s valve; F: Chest computed tomography (CT). Axial thin-section unenhanced CT image revealing uniformly distributed miliary deposits in both lungs. Equipment used for microscopy images: Microscope- Olympus BX41; camera Canon EOS 700D; Acquisition software- QuickPhoto Camera 3.2. No enhancement of the images was performed. The images were acquired at a resolution of 300 DPI.