Association between hemoglobin and chronic kidney disease progression: a secondary analysis of a prospective cohort study in Japanese patients

Table 6 Relationship between Hb and renal function decline in different models

Exposure	Crude model (β,95%CI, P)	Model I (β,95%CI, P)	Model II (β,95%CI, P)	Model III (β,95%CI, P)
Hb	-0.298 (-0.551, -0.045) 0.02118	-0.340 (-0.620, -0.061) 0.01731	-0.436 (-0.778, -0.093) 0.01288	-0.428 (-0.777, -0.079) 0.01638
Hb Quartile
Q1	Ref	Ref	Ref	Ref
Q2	0.767 (-0.847, 2.381) 0.35164	0.789 (-0.802, 2.381) 0.33126	0.745 (-0.876, 2.365) 0.36799	0.976 (-0.631, 2.583) 0.23427
Q3	-0.186 (-1.775, 1.404) 0.81898	0.205 (-1.414, 1.825) 0.80377	-0.163 (-1.949, 1.623) 0.85844	0.059 (-1.719, 1.837) 0.94813
Q4	-1.322 (-2.903, 0.260) 0.10184	-1.509 (-3.250, 0.232) 0.08964	-2.118 (-4.201, -0.034) 0.04661	-1.795 (-3.868, 0.278) 0.08996
P for trend	0.05020	0.07445	0.04345	0.06906

Crude model: we did not adjust other covariants
Model I: we adjust age, gender, BMI, SBP, hypertension, diabetes, history of CVD, and etiology of CKD
Model II: we adjust age, gender, BMI, SBP, hypertension, diabetes, etiology of CKD, history of CVD, UPCR, eGFR, ALB, urinary occult blood, use of RAAS inhibitor, use of calcium channel blocker, use of diuretics
CI Confidence, Ref Reference
Model III: we adjust age(smooth), gender, BMI(smooth), SBP(smooth), hypertension, etiology of CKD, diabetes, history of CVD, UPCR(smooth), eGFR(smooth), ALB(smooth), urinary occult blood, use of RAAS inhibitor, use of calcium channel blocker, use of diuretics
CI Confidence, Ref Reference

ISSN: 1471-2369