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Table 3 Least squares mean change in patient-reported outcomes within each group

From: Patient-reported outcomes in a pilot clinical trial of twice-weekly hemodialysis start with adjuvant pharmacotherapy and transition to thrice-weekly hemodialysis vs conventional hemodialysis

Study Period

Baseline to Week 6

Week 6 to Week 12

Incremental HD

Conventional HD

Incremental HD

Conventional HD

LS mean change (SE)

P value

LS mean change (SE)

P value

LS mean change (SE)

P value

LS mean change (SE)

P value

Model 1

 DSI

−10.3 (4.7)

0.03

−14.0 (4.8)

0.005

−3.3 (3.2)

0.30

−2.7 (3.2)

0.40

 GAD-7

−2.0 (1.0)

0.03

−0.2 (1.0)

0.89

0.5 (0.7)

0.25

−0.5 (0.7)

0.60

 PHQ-9

−2.5 (1.1)

0.04

−2.8 (1.1)

0.01

0.3 (0.6)

0.70

−0.6 (0.6)

0.34

Model 2

 DSI

−9.7 (4.8)

0.05

−13.8 (5.0)

0.009

−3.1 (3.2)

0.34

−2.4 (5.5)

0.67

 GAD-7

−1.9 (1.0)

0.07

−1.5 (1.4)

0.31

0.5 (0.6)

0.46

0.1 (0.6)

0.87

 PHQ-9

−2.5 (1.1)

0.03

−3.5 (1.5)

0.02

−0.3 (0.6)

0.70

−0.5 (0.6)

0.47

  1. Model 1 represents unadjusted analyses; Model 2 includes adjustments for covariates of age, race, gender, baseline urine volume, diabetes mellitus status, and malignancy status. DSI denotes Dialysis Symptom Index, GAD-7 Generalized Anxiety Disorder 7-item, LS least squares, PHQ-9 Patient Health Questionnaire 9-item, SE standard error