Cardiovascular events and mortality in chronic kidney disease in primary care patients with previous type 2 diabetes and/or hypertension. A population-based epidemiological study (KIDNEES)

Table 4 Multivariate adjusted hazard ratios (HR) for mortality, from a Cox proportional hazard model, associated with CKD groups, estimated glomerular filtration rate (eGFR), albuminuria categories and non-controlled HbA1c, in the KIDNEES cohort free of Atherosclerotic Cardiovascular Disease, adjusted for covariables resulting in the variable selection process (n = 398,477)

		HR	Low CI	Up. CI	p value
Group	CKD without HTN/T2D		(Ref.)
	CKD with HTN	0.74	0.72	0.75	< 0.001
	CKD with T2D	1.14	1.10	1.19	< 0.001
	CKD with HTN/T2D	0.81	0.79	0.83	< 0.001
eGFR severity (mL/min/1.63m²)	< 15	2.39	2.19	2.61	< 0.001
	15–29	1.79	1.73	1.87	< 0.001
	30–44	1.51	1.46	1.55	< 0.001
	45–59	1.13	1.10	1.16	< 0.001
	60–89		(Ref.)
	≥ 90	0.82	0.78	0.85	< 0.001
Albuminuria severity	normal to mildly increased		(Ref.)
	moderately increased	1.40	1.37	1.44	< 0.001
	severely increased	1.83	1.75	1.92	< 0.001
Non controlled HbA1c		1.15	1.12	1.17	< 0.001

HR: Pooled Hazard Ratios. CI: Confidence Interval. CKD: Chronic kidney disease. HTN: Hypertension. T2D: Type 2 Diabetes Mellitus
Model adjusted by: age, sex, socioeconomic deprivation index, other primary renal disease, autoimmune disease with CKD risk, Smoking status, Obesity, Heart failure, anemia, hypercholesterolemia, statins, platelet and anticoagulants, aldosterone antagonists, angiotensin converting enzyme inhibitors, Charlson comorbidity. Estimation of covariable effects presented in Supplementary table 6. Model resulting from stepwise backwards selection process based on Akaike Information Criteria starting from model presented in supplementary table 7.

ISSN: 1471-2369