Cardiovascular events and mortality in chronic kidney disease in primary care patients with previous type 2 diabetes and/or hypertension. A population-based epidemiological study (KIDNEES)

Table 5 Multivariate adjusted subdistributional hazard ratios (sHR) for Cardiovascular Event (CVE), considering death as a competitive risk, associated with CKD groups, estimated glomerular filtration rate (eGFR), albuminuria categories, and non-controlled blood pressure and HbA1c in the KIDNEES cohort free of Atherosclerotic Cardiovascular Disease adjusted for covariables resulting in the selection process (n = 398,477).

		sHR	Low CI	Up. CI	p value
Group	CKD without HTN/T2		(Ref.)
	CKD with HTN	1.40	1.34	1.47	< 0.001
	CKD with T2D	1.37	1.26	1.48	< 0.001
	CKD with HTN/T2D	1.70	1.61	1.80	< 0.001
eGFR severity (mL/min/1.63m2)	< 15	0.93	0.73	1.19	0.561
	15–29	1.02	0.92	1.14	0.663
	30–44	1.19	1.12	1.27	< 0.001
	45–59	1.06	1.00	1.12	0.073
	60–89		(Ref.)
	≥ 90	0.94	0.89	0.99	0.016
Albuminuria severity	Normal to mildly increased		(Ref.)
	Moderately increased	1.20	1.10	1.30	0.001
	Severely increased	1.38	1.24	1.53	< 0.001
Systolic blood pressure	≥ 140 mm Hg	1.15	1.12	1.19	< 0.001
Diastolic blood pressure	≥ 90 mm Hg	1.10	1.04	1.16	< 0.001
Non controlled HbA1c		1.35	1.30	1.40	< 0.001

Model adjusted by: age, sex, socioeconomic deprivation index, autoimmune disease with CKD risk, Smoking habit. Obesity. Heart failure, anemia, hypercholesterolemia, platelet and anticoagulants, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists. Estimation of covariable effects presented in Supplementary table 9. Model resulting from stepwise backwards selection process based on Akaike Information Criteria starting from model presented in supplementary table 10.

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