Table 3 Empirical Categories Based on the Quartiles of Annual Change in eGFR
From: Polygenic association of glomerular filtration rate decline in world trade center responders
Middle Quartiles (reference) | Lower Quartile | Upper Quartile | p-value | |
|---|---|---|---|---|
n | 800 | 401 | 400 | |
Age | 54.43 (7.69) | 55.28 (8.73) | 52.35 (8.25) | < 0.001a |
Gender | 740 (93%) | 371 (93%) | 374 (94%) | 0.802b |
Education | 0.398b | |||
No High School Diploma | 20 (3%) | 7 (2%) | 15 (4%) | |
High School Diploma | 148 (18%) | 82 (20%) | 67 (17%) | |
< Bachelor’s Degree | 356 (44%) | 192 (48%) | 192 (48%) | |
BA/BS or Graduate Degree | 235 (29%) | 110 (27%) | 113 (28%) | |
Other or Unknown | 41 (5%) | 10 (2) | 13 (3%) | |
BMI (kg/m²) | 30.99 (5.59) | 30.87 (4.88) | 30.96 (5.43) | 0.906a |
Hypertension | 186 (23%) | 92 (23%) | 85 (21%) | 0.672b |
Diabetes | 44 (6%) | 41 (10%) | 21 (5%) | 0.006c |
Cardiovascular Disease | 5 (< 1%) | 9 (2%) | 4 (1%) | 0.050c |
Baseline eGFR (ml/min/1.73 m²) | 88.55 (13.20) | 84.13 (15.21) | 83.68 (12.77) | < 0.001a |
3rd eGFR measurement (ml/min/1.73 m²) | 86.15 (12.31) | 73.15 (14.51) | 91.76 (10.94) | < 0.001a |
5th eGFR measurement (ml/min/1.73 m²) | 80.47 (11.94) | 70.43 (15.32) | 94.32 (9.17) | < 0.001a |
Average rate of eGFR change (ml/min/1.73m2/year) | -0.75 (0.22) | -1.62 (0.41) | + 0.11 (0.42) | < 0.001a |