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Table 2 Comparison of two groups of ESA interventions

From: Routine laboratory testing in hemodialysis: how frequently is it needed?

 

With ≤ 5 interventions per year for ESA

n = 120

With > 5 interventions per year for ESA

n = 90

P-value

Age, median (IQR)

72 (61, 78)

72 (63, 79.3)

0.422*

Sex, M/F (%)

77/44 (64.2/35.8)

54/36 (60/40)

0.537**

Dialysis vintage (months), Median (IQR)

40 (25, 72)

31 (18, 49.3)

0.011*

Diabetes, n(%)

54 (45)

45 (50)

0.473**

Hypertension, n(%)

116 (96.7)

85 (94.4)

0.502***

Smoking status, n(%)

50 (41.7)

30 (33.3)

0.218**

CAD, n(%)

53 (44.2)

29 (32.6)

0.09**

Cancer, n(%)

14 (11.7)

14 (15.6)

0.412**

RAAS inhibitors intake, n(%)

12 (10)

11 (12.2)

0.61**

Monthly dose of ESA, Median (IQR)

22333.5 (10,250, 45624.8)

21,333 (17249.8, 37,500)

0.853*

Monthly dose of IV iron, Mean ± SD

1.04 ± 1.02

1.29 ± 1.13

0.005****

Yearly number of interventions in ESA prescription

Mean ± SD

2.8 ± 1.7

7.1 ± 1.1

< 0.001****

Yearly number of interventions in IV iron prescription

Mean ± SD

3.7 ± 2.7

5.0 ± 2.1

< 0.001****

Hemoglobin over one year, Median (IQR)

11.5 (10.9, 11.9)

11.0 (10.6, 11.4)

< 0.001*

Ferritin over one year, Mean ± SD

459.8 ± 260.9

633.8 ± 219.2

< 0.001****

TSAT over one year, Median (IQR)

0.25 (0.20, 0.29)

0.28 (0.22, 0.35)

0.002*

Serum calcium over one year, Mean ± SD

9.0 ± 0.5

9.0 ± 0.4

0.770****

Serum phosphate over one year, Mean ± SD

4.5 ± 1.04

4.3 ± 1.1

0.217****

PTH, over one year, Median (IQR)

270.0 (166.8, 509.0)

175.4 (101.4, 312.7)

0.001*

URR over one year,

Mean ± SD

0.74 ± 0.05

0.77 ± 0.05

0.002****

Serum potassium over one year, Median (IQR)

5.1 (4.8, 5.6)

5.1 (4.7, 5.4)

0.215*

  1. *Mann Whitney test and **Chi Square test ***Fischer’s Exact test ****Independent t-test; P-value < 0.05 is statistically significant