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Table 3 A comparison of the ability to predict microalbuminuria or worse using the dipstick proteinuria, uPCR, or uACR in non-diabetic patients with G1-4 and all qualitative proteinuria findings

From: A comparison of the utility of the urine dipstick and urine protein-to-creatinine ratio for predicting microalbuminuria in patients with non-diabetic lifestyle-related diseases -a comparison with diabetes

 

AUC

SE

P Value

COf

Sensitivity

Specificity

PPV

NPV

Distance

Se + Sp-1

P Value vs

P Value vs Sum of

P Value vs Sum of

P[1,2,3dipstick ≥ ( ±)]b

1,2,3dipstick scoresc

1,2,3uPCR

1st urine protein dipstick score

0.642

0.024

 < 0.001

0.5 g

0.394

0.880

0.763

0.597

0.618

0.273

0.0015

0.0003

 < 0.0001

2nd urine protein dipstick score

0.647

0.021

 < 0.001

0.5

0.348

0.937

0.844

0.594

0.655

0.285

0.0023

0.0039

 < 0.0001

3rd urine protein dipstick score

0.643

0.022

 < 0.001

0.5

0.368

0.911

0.803

0.595

0.638

0.279

0.0013

0.0011

 < 0.0001

Probability[1,2,3dipstick ≥ ( +)]a

0.643

0.022

 < 0.001

0.650

0.342

0.930

0.828

0.590

0.662

0.272

0.0032

0.0008

 < 0.0001

Probability[1,2,3dipstick ≥ ( ±)]b

0.701

0.026

 < 0.001

0.532

0.555

0.797

0.729

0.646

0.489

0.352

-

0.801

 < 0.0001

Sum of 1,2,3dipstick scoresc

0.702

0.025

 < 0.001

0.5

0.555

0.797

0.729

0.646

0.489

0.352

0.801

-

 < 0.0001

1st uPCR (g/gCr)

0.826

0.023

 < 0.001

0.08

0.729

0.747

0.739

0.738

0.371

0.476

 < 0.0001

 < 0.0001

 < 0.0001

    

0.10

0.658

0.842

0.803

0.715

0.377

0.500

   

2nd uPCR (g/gCr)

0.867

0.020

 < 0.001

0.07

0.794

0.804

0.799

0.799

0.285

0.597

 < 0.0001

 < 0.0001

0.034

3rd uPCR (g/gCr)

0.831

0.024

 < 0.001

0.07

0.794

0.741

0.750

0.785

0.332

0.534

 < 0.0001

 < 0.0001

0.00018

    

0.09

0.677

0.873

0.840

0.734

0.347

0.551

   

Sum of 1,2,3uPCR (g/gCr)d

0.898

0.017

 < 0.001

0.23

0.832

0.848

0.843

0.838

0.226

0.680

 < 0.0001

 < 0.0001

-

Probability(1,2,3uPCR)e

0.900

0.017

 < 0.001

0.438

0.806

0.880

0.868

0.822

0.228

0.686

 < 0.0001

 < 0.0001

0.470

1st uACR (mg/gCr)

0.932

0.014

 < 0.001

30

0.923

0.867

0.872

0.919

0.154

0.790

 < 0.0001

 < 0.0001

0.091

2nd uACR (mg/gCr)

0.946

0.012

 < 0.001

30

0.923

0.854

0.861

0.918

0.165

0.777

 < 0.0001

 < 0.0001

0.0094

3rd uACR (mg/gCr)

0.915

0.017

 < 0.001

30

0.845

0.880

0.873

0.853

0.196

0.725

 < 0.0001

 < 0.0001

0.410

    

31

0.826

0.905

0.895

0.841

0.198

0.731

   
  1. uPCR urine protein-to-creatinine ratio, uACR urine albumin-to-creatinine ratio, PPV Positive predictive value, NPV Negative predictive value, Se Sensitivity, Sp Specificity
  2. aProbability of micro- and macroalbuminuria by a logistic model using the 1st, 2nd and 3rd dipstick urine protein. Dammy variable dipstick proteinuria ≥ ( +);1 and ( ±)(-);0, respectively. Supplemental Table 4
  3. bProbability of micro- and macroalbuminuria by a logistic model using the 1st, 2nd and 3rd dipstick urine protein. Dammy variable dipstick proteinuria ≥ ( ±);1 and (-);0, respectively. Supplemental Table 4, 5
  4. cSum of the 1st, 2nd and 3rd urine protein dipstick scores. Urine protein dipstick score were defined as dipstick(-):0,( ±):0.5, ( +):1, 2( +):2, and 3( +):3, respectively
  5. dSum of the 1st, 2nd,and 3rd uPCR
  6. eProbability of micro- and macroalbuminuria by a logistic model using the 1st, 2nd, and 3rd uPCRs. Supplemental Table 6
  7. fCO of minimum distance on the ROC curve closest to the (0,1) or Youden's Index
  8. gCO 0.5 on the dipstick test denotes dipstick proteinuria trace
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BMC Nephrology

ISSN: 1471-2369

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