Skip to main content
Fig. 5 | BMC Nephrology

Fig. 5

From: Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways

Fig. 5

Ntrk1 knockdown alleviated glomerulus injury in MsPGN rat. A Ntrk1 mRNA expression in glomerulus of rats in the three groups was explored using qRT-PCR. B Ntrk1 protein expression in glomerulus of rats in shNtrk1 group was researched by Western blot. C The Ntrk1 protein expression in glomerulus of rats in each group was detected after 7 days of Thy1.1 monoclonal antibody injection. D After 7 days of Thy1.1 monoclonal antibody injection, PAS staining was performed on kidney tissues to research the total cells per glomerulus cross-section and mesangial matrix score. E IHC was conducted on kidney tissues to detect Ki67 positive cells on day 7 of Thy1.1 monoclonal antibody injection. F On day 7 of Thy1.1 monoclonal antibody injection, the urine of rats in each group was collected to assess the level of urinary protein. G On day 7 of Thy1.1 monoclonal antibody injection, the mRNA expression of inflammatory factors (IFN-γ, TNF-α and IL-6) in glomerulus of rats in each group was evaluated using qRT-PCR. H After 7 days of Thy1.1 monoclonal antibody injection, the activation of STAT3, p38 and ERK signaling pathways in glomerulus was explored by Western blot. ** P < 0.01

Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us