Table 3 Correlation between clinical manifestations and pathological findings categorized by MEST-C scores

Mesangial hypercellularity

M0

(n = 15)

M1

(n = 32)

Odds ratio (95%CI)

p-value

Adjusted odds ratio (95%CI)

p-value

Hypertension

4 (26.67)

17 (53.13)

3.12 (0.82 – 11.89)

0.096

1.75 (0.37 – 8.23)

0.476

Edema

5 (33.33)

15 (46.88)

1.76 (0.49 – 6.34)

0.384

Microscopic hematuria

5 (33.33)

25 (78.13)

7.14 (1.83 – 27.88)

0.005

Gross hematuria

2 (13.33)

8 (25)

2.17 (0.40 – 11.74)

0.370

Significant proteinuria

9 (60)

13 (40.63)

0.46 (0.13 – 1.59)

0.219

0.44 (0.12 – 1.68)

0.232

Nephrotic range proteinuria

5 (33.33)

17 (53.13)

2.27 (0.63 – 8.14)

0.210

AKI/RPGN

2 (13.33)

12 (37.50)

3.90 (0.75 – 20.34)

0.106

3.12 (0.47 – 20.85)

0.240

Median MAP (IQR)

88.6 (86.3—92)

90.8 (82.3 – 106.15)

1.03 (0.99 – 1.08)

0.171

Median UPCR (IQR)

0.99(0.7 – 2.1)

2.6 (0.98 – 6.65)

1.12

(0.92 – 1.35)

0.260

Endocapillary hypercellularity

E0 (n = 36)

E1 (n = 11)

Odds ratio (95%CI)

p-value

Adjusted odds ratio (95%CI)

p-value

Hypertension

13 (36.11)

8 (72.73)

4.72 (1.06 – 20.96)

0.041

2.22 (0.20 – 24.52)

0.517

Edema

12 (33.33)

8 (72.73)

5.33 (1.19 – 23.83)

0.028

3.45 (0.45 – 26.14)

0.231

Microscopic hematuria

19 (52.78)

11 (100)

NA

NA

Gross hematuria

10 (27.78)

-

NA

NA

Significant proteinuria

21 (58.33)

1 (9.09)

0.07 (0.01 – 0.62)

0.017

0.02 (0.001 – 0.93)

0.046

Nephrotic range proteinuria

13 (36.11)

9 (81.82)

7.96 (1.49 – 42.56)

0.015

0.21 (0.008 – 5.35)

0.344

AKI/RPGN

9 (25)

5 (45.45)

2.5 (0.61 – 10.20)

0.202

Median MAP (IQR)

88.15 (81.95 – 95.6)

103 (90.6—118)

1.04 (1.00 – 1.08)

0.052

1.03 (0.97 – 1.09)

0.354

Median UPCR (IQR)

1.46 (0.7 – 4.66)

6.11 (3.6 – 9.1)

1.13 (0.97 – 1.31)

0.105

Segmental glomerulosclerosis

S0 (n = 27)

S1 (n = 20)

Odds ratio (95%CI)

p-value

Adjusted odds ratio (95%CI)

p-value

Hypertension

7 (25.93)

14 (70)

6.67

(1.84 – 24.14)

0.004

7.87

(1.65 – 37.59)

0.010

Edema

10 (37.04)

10 (50)

1.70 (0.53 – 5.50)

0.376

Microscopic hematuria

15 (55.56)

15 (75)

2.40 (0.68 – 8.50)

0.175

Gross hematuria

8 (29.63)

2 (10)

0.26 (0.05 – 1.41)

0.120

Significant proteinuria

12 (44.44)

10 (50)

1.25 (0.39 – 3.99)

0.706

Nephrotic range proteinuria

12 (44.44)

10 (50)

1.25 (0.39 – 3.99)

0.706

AKI/RPGN

6 (22.22)

8 (40)

2.33 (0.65 – 8.34)

0.192

0.72

(0.14 – 3.81)

0.704

Mean MAP (SD)

89.19 (13.62)

100.39 (20.76)

1.04 (1.00 – 1.08)

0.044

Median UPCR (IQR)

1.25

(0.7 – 5.5)

2.6

(1.17 – 6.80)

0.99 (0.86 – 1.13)

0.835

Tubular atrophy/interstitial fibrosis

T0

(n = 33)

T1/T2

(n = 14)

Odds ratio (95%CI)

p-value

Adjusted odds ratio (95%CI)

p-value

Hypertension

11 (33.33)

10 (71.43)

5 (1.27 – 19.62)

0.021

1.86 (0.27 – 12.86)

0.527

Edema

13 (39.39)

7 (50)

1.54 (0.44 – 5.42)

0.502

Microscopic hematuria

18 (54.55)

12 (85.71)

5 (0.96 – 25.94)

0.055

Gross hematuria

9 (27.27)

1 (7.14)

0.21 (0.02 – 1.80)

0.153

Significant proteinuria

19 (57.58)

3 (21.43)

0.20 (0.05 – 0.86)

0.030

Nephrotic range proteinuria

12 (36.36)

10 (71.43)

4.38 (1.12 – 17.03)

0.033

3.33 (0.77 – 14.32)

0.106

AKI/RPGN

7 (21.21)

7 (50)

3.71 (0.97 – 14.18)

0.055

Median MAP (IQR)

88

(81.6—92)

102.15

(90.6—120)

1.05 (1.01 – 1.09)

0.020

1.03 (0.98 – 1.09)

0.255

Median UPCR (IQR)

1.36 (0.70 – 3.38)

6.28 (3.1 – 7.33)

1.15 (0.98 – 1.34)

0.081

Crescent

C0

(n = 35)

C1/C2

(n = 12)

Odds ratio (95%CI)

p-value

Adjusted odds ratio (95%CI)

p-value

Hypertension

11 (31.43)

10 (83.33)

10.91 (2.04 – 58.39)

0.005

2.42 (0.23 – 25.25)

0.461

Edema

12 (34.29)

8 (66.67)

3.83 (0.96 – 15.37)

0.058

Microscopic hematuria

22 (62.86)

8 (66.67)

1.18 (0.30 – 4.71)

0.813

Gross hematuria

6 (17.14)

4 (33.33)

2.42 (0.55 – 10.70)

0.245

Significant proteinuria

19 (54.29)

3 (25)

0.28 (0.06 – 1.22)

0.089

Nephrotic range proteinuria

13 (37.14)

9 (75)

5.08 (1.16 – 22.20)

0.031

4.31 (0.72 – 25.90)

0.111

AKI/RPGN

7 (20)

7 (58.33)

5.6 (1.36 – 23.06)

0.017

1.92 (0.26 – 14.25)

0.522

Mean MAP (SD)

88.83 (11.51)

108.91 (24.02)

1.07 (1.02 – 1.13)

0.004

1.04 (0.98 – 1.11)

0.223

Median UPCR (IQR)

1.18

(0.69 – 3.6)

6.27

(3.83 – 7.33)

1.14 (0.98 – 1.33)

0.082