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Table 3 Association between exposure to macrolide antibiotics and IRR of AKI in PPI users

From: Use of proton pump inhibitors and macrolide antibiotics and risk of acute kidney injury: a self-controlled case series study

 

Number of episodes

Person-day

IRR (95% CI)

Adjusted IRR* (95% CI)

Stage 1 or higher AKI

With PPIs alone

336

196,105

Reference

Reference

With PPIs and macrolide antibiotics

49

22,626

1.26 (0.94–1.71)

0.82 (0.60–1.13)

Stage 2 or higher AKI

With PPIs alone

89

69,484

Reference

Reference

With PPIs and macrolide antibiotics

13

10,006

1.01 (0.57–1.82)

0.73 (0.40–1.34)

  1. *Adjusted for the use of potentially nephrotoxic antibiotics and baseline eGFR
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BMC Nephrology

ISSN: 1471-2369

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