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Table 3 Association of measures of adiposity with incident chronic kidney disease (CKD)

From: Lipid accumulation product, visceral adiposity index and risk of chronic kidney disease

 

Events/N

Proportion

Unadjusted

Model 1

Model 2

Model 3

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

VAI

 Continuous (per doubling)

1127/11538

10%

1.31 (1.24, 1.40)

1.41 (1.32, 1.51)

1.23 (1.15, 1.32)

1.12 (1.04, 1.20)

 Quartiles

  ≤ 2.31

215/3166

7%

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

  2.32–3.64

277/3033

9%

1.39 (1.14, 1.68)

1.37 (1.13, 1.67)

1.22 (0.99, 1.48)

1.13 (0.92, 1.38)

  3.65–5.91

319/2826

11%

1.82 (1.51, 2.19)

1.94 (1.60, 2.35)

1.61 (1.33, 1.96)

1.40 (1.15, 1.72)

  ≥ 5.92

316/2513

13%

1.99 (1.65, 2.40)

2.30 (1.89, 2.79)

1.60 (1.31, 1.96)

1.26 (1.02, 1.55)

LAP

 Continuous (per doubling)

1127/11538

10%

1.42 (1.33, 1.50)

1.54 (1.44, 1.64)

1.32 (1.23, 1.41)

1.21 (1.13, 1.29)

 Quartiles

  ≤ 124.89

195/3175

6%

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

  124.9–208.07

262/3057

9%

1.40 (1.15, 1.71)

1.33 (1.09, 1.63)

1.16 (0.95, 1.43)

1.12 (0.91, 1.38)

  208.08–339.57

325/2794

12%

2.01 (1.67, 2.43)

2.03 (1.67, 2.46)

1.62 (1.32, 1.97)

1.45 (1.18, 1.78)

  ≥ 339.58

345/2512

14%

2.42 (2.01, 2.93)

2.90 (2.38, 3.52)

1.91 (1.56, 2.35)

1.51 (1.22, 1.87)

BMI

 Continuous (per doubling)

1127/11538

10%

2.69 (2.15, 3.37)

4.47 (3.48, 5.74)

2.73 (2.08, 3.56)

2.10 (1.60, 2.76)

 Quartiles

  ≤ 25.1

191/2849

7%

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

  25.2–28.3

273/3096

9%

1.30 (1.06, 1.58)

1.38 (1.13, 1.69)

1.26 (1.03, 1.55)

1.22 (0.99, 1.50)

  28.4–32.5

292/2978

10%

1.52 (1.25, 1.84)

1.74 (1.43, 2.13)

1.40 (1.14, 1.72)

1.30 (1.05, 1.60)

  > 32.5

371/2615

14%

2.24 (1.86, 2.70)

3.09 (2.53, 3.78)

2.17 (1.75, 2.68)

1.81 (1.46, 2.25)

Waist Circumference

 Continuous (per doubling)

1127/11538

10%

4.42 (3.30, 5.92)

7.57 (5.48, 10.47)

3.62 (2.57, 5.10)

2.66 (1.88, 3.77)

 Quartiles

  ≤ 86.3

256/3508

7%

1.00 (ref)

1.00 (ref)

1.00 (ref)

1.00 (ref)

  86.4–95.2

215/2710

8%

1.04 (0.86, 1.27)

1.11 (0.91, 1.36)

0.97 (0.79, 1.19)

0.97 (0.78, 1.19)

  95.3–105.4

290/2874

10%

1.37 (1.14, 1.64)

1.57 (1.29, 1.91)

1.23 (1.01, 1.50)

1.13 (0.92, 1.38)

  > 105.4

366/2446

15%

2.22 (1.87, 2.64)

2.91 (2.41, 3.51)

1.91 (1.57, 2.34)

1.64 (1.33, 2.01)

  1. Model 1: adjusted for age, sex, race
  2. Model 2: Model 1 + prevalent CHD, prevalent stroke, HTN, DM, smoking status
  3. Model 3: Model 2+ eGFR, UACR
  4. Abbreviations: VAI visceral adiposity index, LAP lipid accumulation product, BMI body mass index, CHD coronary heart disease, HTN hypertension, DM diabetes mellitus, eGFR estimated glomerular filtration rate, UACR urine albumin-to-creatinine ratio