Association between anemia and serum Klotho in middle-aged and older adults

BMC Nephrology

Table 3 Threshold effects of S-Klotho (per 100 pg/mL) for anemia were analyzed in NHANES 2007-2016 using a two-piece regression model

Exposure	anemia, Adjusted OR (95% CI), P-value
Fitting by the standard linear model	0.956 (0.936, 0.976) <0.001
Fitting by the two-piecewise linear model
Turning point (K)	9.746
< Turning point (K)	0.891 (0.857, 0.925) <0.001
>Turning point (K)	1.018 (0.985, 1.052) 0.298
Predicted at Turning point (K)	-2.471 (-2.570, -2.372)
Log likelihood ratio test	<0.001

Adjusted the covariates: age, gender, race, marital status (having a partner, others), poverty-to-income ratio (<1.3,1.3-2.9, \(>=\)3.0), education level (< high school, high school, > high school), alcohol intake (no, yes), smoke (never, former, now), moderate-vigorous physical activity, body mass index (<25.0, 25.0-29.9,\(\ge\)30.0), high waist circumference, phosphorus, calcium, serum iron, albumin, uric acid, urinary albumin/creatinine ratio, estimated glomerular filtration rate, serum 25-hydroxyvitamin D, DFE deficiency, Vitamin B12 deficiency, Iron intake deficiency, angina, heart attack, coronary heart disease, congestive heart failure, stroke, hypertension, hyperlipidemia, diabetes, chronic kidney diseases, cancer, and rheumatoid arthritis.
Abbreviations: OR odd ratio, CI confidence interval

ISSN: 1471-2369