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Table 4 Subgroup analyses for the association between anemia and quartiles of S-Klotho (pg/mL) among the study participants, weighted

From: Association between anemia and serum Klotho in middle-aged and older adults

anemia

S-Klotho Quartile, OR (95% CI)

P-interaction

 

Quartile 1 (496.7, 613.9)

Quartile 2 (690.9, 763.4)

Quartile 3 (840.8, 935.5)

Quartile 4 (1060.8, 1330.9)

 

Age\(^{a}\)

    

0.561

     40-59

1.38(1.00, 1.91)

1.17 (0.86, 1.60)

1.00 (0.73, 1.35)

Reference

 

     60-79

1.85 (1.31,2.62)

1.57 (1.11, 2.21)

1.12 (0.78, 1.62)

Reference

 

Gender\(^{b}\)

    

0.005

     Male

2.81 (1.89,4.19)

1.79 (1.25, 2.58)

1.39 (0.96, 2.03)

Reference

 

     Female

1.15 (0.85,1.54)

1.17 (0.85, 1.59)

0.93 (0.69, 1.26)

Reference

 

Body mass index\(^{c}\)

    

0.418

     < 25.0 kg/m\(^{2}\)

1.53 (0.99,2.34)

1.53 (0.94, 2.49)

0.87 (0.56, 1.36)

Reference

 

     25.0-29.9 kg/m\(^{2}\)

1.43 (0.88,2.33)

0.87 (0.53, 1.43)

0.91 (0.58, 1.43)

Reference

 

     \(\ge\) 30.0 kg/m\(^{2}\)

1.66 (1.15, 2.40)

1.51 (1.09, 2.11)

1.25 (0.86, 1.83)

Reference

 

Diabetes\(^{d}\)

    

0.005

     no

1.25 (0.97, 1.60)

1.11 (0.82, 1.51)

0.93 (0.71, 1.22)

Reference

 

     yes

2.70 (1.80, 4.05)

2.06 (1.32, 3.21)

1.42 (0.91, 2.20)

Reference

 

Chronic kidney disease\(^{e}\)

    

0.186

     no

1.40 (1.05, 1.87)

1.37 (1.05, 1.79)

1.00 (0.73, 1.36)

Reference

 

     yes

1.90 (1.26, 2.89)

1.11 (0.72, 1.72)

1.14 (0.75, 1.75)

Reference

 
  1. a: Modified for gender, race, marital status (having a partner, others), poverty-to-income ratio (<1.3,1.3-2.9, \(>=\)3.0), education level (< high school, high school, > high school), alcohol intake (no, yes), smoke (never, former, now), moderate-vigorous physical activity, body mass index (<25.0, 25.0-29.9, \(\ge\)30.0), high waist circumference, phosphorus, calcium, serum iron, albumin, uric acid, urinary albumin/creatinine ratio, estimated glomerular filtration rate, serum 25-hydroxyvitamin D, DFE deficiency, Vitamin B12 deficiency, Iron intake deficiency, angina, heart attack, coronary heart disease, congestive heart failure, stroke, hypertension, hyperlipidemia, diabetes, chronic kidney diseases, cancer, and rheumatoid arthritis.
  2. b: Modified for age, race, marital status (having a partner, others), poverty-to-income ratio(<1.3,1.3-2.9, \(>=\)3.0), education level (< high school, high school, > high school), alcohol intake (no, yes), smoke (never, former, now), moderate-vigorous physical activity, body mass index (<25.0, 25.0-29.9, \(\ge\)30.0), high waist circumference, phosphorus, calcium, serum iron, albumin, uric acid, urinary albumin/creatinine ratio, estimated glomerular filtration rate, serum 25-hydroxyvitamin D, DFE deficiency, Vitamin B12 deficiency, Iron intake deficiency, angina, heart attack, coronary heart disease, congestive heart failure, stroke, hypertension, hyperlipidemia, diabetes, chronic kidney diseases, cancer, and rheumatoid arthritis.
  3. c: Modified for age, gender, race, marital status (having a partner, others), poverty-to-income ratio(<1.3,1.3-2.9, \(>=\)3.0), education level (< high school, high school, > high school), alcohol intake (no, yes), smoke (never, former, now), moderate-vigorous physical activity, high waist circumference, phosphorus, calcium, serum iron, albumin, uric acid, urinary albumin/creatinine ratio, estimated glomerular filtration rate, serum 25-hydroxyvitamin D, DFE deficiency, Vitamin B12 deficiency, Iron intake deficiency, angina, heart attack, coronary heart disease, congestive heart failure, stroke, hypertension, hyperlipidemia, diabetes, chronic kidney diseases, cancer, and rheumatoid arthritis.
  4. d: Modified for age, gender, race, marital status (having a partner, others), poverty-to-income ratio(<1.3,1.3-2.9, \(>=\)3.0), education level (< high school, high school, > high school), alcohol intake (no, yes), smoke (never, former, now), moderate-vigorous physical activity, body mass index (<25.0, 25.0-29.9, \(\ge\)30.0), high waist circumference, phosphorus, calcium, serum iron, albumin, uric acid, urinary albumin/creatinine ratio, estimated glomerular filtration rate, serum 25-hydroxyvitamin D, DFE deficiency, Vitamin B12 deficiency, Iron intake deficiency, angina, heart attack, coronary heart disease, congestive heart failure, stroke, hypertension, hyperlipidemia, chronic kidney diseases, cancer, and rheumatoid arthritis.
  5. e: Modified for age, gender, race, marital status (having a partner, others), poverty-to-income ratio(<1.3,1.3-2.9, \(>=\)3.0), education level (< high school, high school, > high school), alcohol intake (no, yes), smoke (never, former, now), moderate-vigorous physical activity, body mass index (<25.0, 25.0-29.9, \(\ge\)30.0), high waist circumference, phosphorus, calcium, serum iron, albumin, uric acid, urinary albumin/creatinine ratio, estimated glomerular filtration rate, serum 25-hydroxyvitamin D, DFE deficiency, Vitamin B12 deficiency, Iron intake deficiency, angina, heart attack, coronary heart disease, congestive heart failure, stroke, hypertension, hyperlipidemia, diabetes, cancer, and rheumatoid arthritis.
  6. Abbreviations: OR odd ratio, CI confidence interval
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BMC Nephrology

ISSN: 1471-2369

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