Table 1 Baseline characteristics for the cohort and individual high-risk group
Variables | Entire group (N = 250,574) | Age older than 70 years old (N = 15,775) | Recipient BMI > 35 kg/m2 (N = 25,976) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Low (n = 84,903) | Medium (n = 83,883) | High (n = 81,788) | p-value | Low (n = 5254) | Medium (n = 5192) | High (n = 5329) | p-value | Low (n = 8674) | Medium (n = 8630) | High (n = 8672) | p-value | |
Recipient and Transplant Factors | ||||||||||||
 Age (%) |  |  |  |  < .0001 |  |  |  | - |  |  |  | 0.4027 |
  18–35 years | 16.9% | 16.7% | 16.1% | - | - | - | 13.3% | 12.4% | 12.9% | |||
  36–50 years | 30.4% | 31.1% | 30.5% |  |  |  | 34.1% | 34.7% | 34.4% | |||
  51–65 years | 39.0% | 39.3% | 39.3% | - | - | - | 42.9% | 42.9% | 42.3% | |||
   > 65 years | 13.7% | 12.9% | 14.1% | 100% | 100% | 100% | 9.7% | 10% | 10.4% | |||
 Gender (%) |  |  |  |  < .001 |  |  |  | 0.9744 |  |  |  | 0.0078 |
  Male | 61.5% | 60.1% | 60.0% | 66.2% | 66.4% | 66.2% | 55.3% | 52.9% | 54.3% | |||
  Female | 38.5% | 39.9% | 40.0% | 33.8% | 33.6% | 33.8% | 44.7% | 47.1% | 45.7% | |||
 Race (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  White | 55.5% | 48.5% | 54.8% | 66.1% | 67.4% | 68.1% | 54.2% | 49.1% | 54.7% | |||
  Black | 25.1% | 28.1% | 23.3% | 18.2% | 16.6% | 14.9% | 28.8% | 38% | 31.4% | |||
  Hispanic | 12.9% | 16.0% | 13.8% | 9.8% | 9.7% | 8.8% | 12.7% | 9.5% | 11.1% | |||
  Other | 6.4% | 7.4% | 8.1% | 6% | 6.3% | 8.3% | 4.3% | 3.4% | 2.8% | |||
BMI (kg/m2) | 27.8 | 27.5 | 27.6 |  < .0001 | 27.5 | 27.3 | 27.4 | 0.1098 | 37.71 | 37.91 | 38.22 |  < .0001 |
 Time on dialysis (months) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  0 | 20.0% | 21.1% | 26.8% | 20.6% | 22.5% | 28.1% | 16.5% | 17.1% | 22.6% | |||
  1–12 | 9.6% | 8.7% | 10.2% | 7% | 7.9% | 7.3% | 7.9% | 7% | 9% | |||
   > 12 to 24 | 14.7% | 13.9% | 13.3% | 15.2% | 15.1% | 14.7% | 14.2% | 12.5% | 14.3% | |||
   > 24 | 55.6% | 56.4% | 49.7% | 57.3% | 54.5% | 49.9% | 61.4% | 63.4% | 54.1% | |||
 Time on waiting list (years) |  |  |  |  < .0001 |  |  |  | 0.0048 |  |  |  |  < .0001 |
  0–1 | 41.7% | 41.0% | 43.3% | 37.8% | 40% | 40.3% | 40.4% | 36% | 43.4% | |||
  1 to 3 | 35.2% | 35.0% | 32.2% | 36.9% | 37.9% | 37.3% | 36.2% | 35.9% | 32.5% | |||
   > 3 | 23.1% | 24.0% | 24.5% | 25.3% | 22.1% | 22.4% | 23.4% | 28.1% | 24.1% | |||
 HLA Mismatch Level |  |  |  | 0.0006 |  |  |  | 0.2117 |  |  |  |  < .0001 |
  0 | 9.2% | 9.1% | 9.2% | 6.4% | 7% | 6.2% | 8.7% | 8.9% | 8.8% | |||
  1 to 2 | 12.2% | 12.0% | 12.5% | 12.1% | 11.4% | 11.1% | 10.9% | 10% | 12.4% | |||
  3 to 6 | 78.5% | 78.9% | 78.3% | 81.6% | 81.6% | 82.8% | 80.4% | 81.1% | 78.8% | |||
 PRA (%) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
 0 | 57.8% | 56.8% | 59.4% | 63.1% | 67.8% | 66.2% | 58.7% | 56.9% | 60.9% | |||
  0–20 | 18.1% | 16.0% | 15.5% | 17% | 14% | 15.7% | 16.8% | 15.9% | 15% | |||
  20–80 | 13.8% | 15.2% | 14.3% | 13.4% | 11.4% | 11.9% | 14.5% | 15.4% | 14.2% | |||
   > 80 | 10.2% | 12.0% | 10.8% | 6.5% | 6.8% | 6.2% | 9.9% | 11.8% | 9.8% | |||
 Induction |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  Basiliximab | 29.2% | 22.3% | 20.2% | 33.2% | 34.3% | 25.9% | 23.5% | 23.7% | 14.1% | |||
  Alemtuzumab | 7.7% | 11.0% | 13.8% | 7.9% | 8.3% | 9.5% | 10.2% | 8.9% | 21.7% | |||
  Thymoglobulin | 41.1% | 44.0% | 47.4% | 37.1% | 38% | 47.1% | 47.1% | 45.7% | 45.8% | |||
  Other | 0.7% | 0.5% | 0.9% | 0.5% | 0.2% | 0.4% | 0.3% | 0.6% | 0.8% | |||
  Missing | 21.3% | 22.2% | 17.8% | 21.3% | 19.1% | 17.1% | 18.8% | 21.1% | 17.6% | |||
 Year of transplantation |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  2000 ~ 2005 | 34.1% | 30.8% | 28.2% | 22.8% | 23.6% | 19.8% | 28.1% | 25.3% | 23.5% | |||
  2006 ~ 2011 | 36.0% | 37.0% | 37.1% | 38% | 40.4% | 40.2% | 37% | 39.7% | 38.8% | |||
  2012 ~ 2016 | 29.9% | 32.2% | 34.7% | 39.2% | 36% | 40% | 34.9% | 34.9% | 37.7% | |||
Donor Factors | ||||||||||||
Age (years) | 38.9 | 38.2 | 39.9 |  < .0001 | 45.6 | 47 | 47.5 |  < .0001 | 39.38 | 39.64 | 40.19 | 0.0024 |
Gender |  |  |  |  < .0001 |  |  |  | 0.02 |  |  |  |  < .0001 |
 Male | 53.1% | 53.3% | 51.2% | 52% | 51.5% | 49.4% | 54.1% | 55.2% | 51.5% | |||
 Female | 46.9% | 46.7% | 48.8% | 48% | 48.5% | 50.6% | 45.9% | 44.8% | 48.5% | |||
Race |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
 White | 72.6% | 67.2% | 69.8% | 75.4% | 76.5% | 73.1% | 73.7% | 70.3% | 71.7% | |||
 Black | 11.9% | 13.8% | 12.2% | 10.9% | 10.5% | 10.6% | 11.6% | 16.8% | 14.9% | |||
 Hispanic | 12.0% | 14.4% | 13.5% | 9.8% | 9.7% | 11.4% | 11.2% | 9.9% | 11.1% | |||
 Other | 3.6% | 4.5% | 4.4% | 3.9% | 3.3% | 4.9% | 3.6% | 3% | 2.3% | |||
BMI | 26.9 | 27.0 | 26.99 | 0.001 | 27.4 | 27.8 | 27.5 | 0.02 | 27.64 | 27.78 | 28.11 |  < .0001 |
Hypertension | 17.4% | 18.3% | 16.7% |  < .0001 | 30.8% | 32.4% | 32.7% | 0.09 | 20.8% | 21.6% | 18.9% |  < .0001 |
Cause of death |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  | 0.35 |
 Anoxia | 22.4% | 23.6% | 25.1% | 22.4% | 23.7% | 24.5% | 24% | 25.5% | 25.2% | |||
 CVA | 34.4% | 35.0% | 35.2% | 43.8% | 46.9% | 47.6% | 34.2% | 34.2% | 34.1% | |||
 Other | 43.2% | 41.4% | 39.6% | 33.8% | 29.4% | 28% | 41.7% | 40.3% | 40.7% | |||
Cold ischemia time (hours) |  |  |  |  < .0001 |  |  |  |  < .0001 |  |  |  |  < .0001 |
  < 12 | 54.6% | 52.6% | 58.4% | 48% | 46% | 47.2% | 53.1% | 50.5% | 58.2% | |||
 12 to 24 | 34.6% | 34.8% | 26.7% | 40.1% | 41.2% | 28.8% | 36% | 36.1% | 27.6% | |||
  > 24 | 10.9% | 12.6% | 15.0% | 12% | 12.9% | 24% | 10.9% | 13.4% | 14.2% | |||