The level of serum albumin is associated with renal prognosis and renal function decline in patients with chronic kidney disease

Table 4 Relationship between ALB and the renal composite endpoint in different models

Exposure	Crude model (HR,95%CI, P )		Model I (HR,95%CI, P )		Model II (HR,95%CI, P )		Model III (HR,95%CI, P )
ALB	0.34 (0.29, 0.41)	< 0.001	0.44 (0.36, 0.54)	< 0.001	0.61 (0.45, 0.81)	< 0.001	0.68 (0.50, 0.92)	< 0.05
ALB Quartile
Q1	Ref		Ref		Ref		Ref
Q2	0.34 (0.25, 0.48)	< 0.001	0.44 (0.31, 0.62)	< 0.001	0.70 (0.47, 1.02)	0.06	0.71 (0.48, 1.05)	0.08
Q3	0.19 (0.13, 0.29)	< 0.001	0.27 (0.18, 0.41)	< 0.001	0.45 (0.29, 0.70)	< 0.001	0.50 (0.31, 0.79)	< 0.05
Q4	0.10 (0.06, 0.15)	< 0.001	0.15 (0.09, 0.25)	< 0.001	0.43 (0.25, 0.73)	< 0.05	0.65 (0.38, 1.13)	0.13
P for trend	< 0.001		< 0.001		< 0.001		< 0.05

Crude model: we did not adjust other covariants
Model I: we adjust gender, age, BMI, hypertension, SBP, history of CVD, diabetes, and etiology of CKD
Model II: we adjust age, BMI, gender, SBP, diabetes, hypertension, etiology of CKD, use of calcium channel blocker, UPCR, history of CVD, eGFR, urinary occult blood, Hb, use of RAAS inhibitor, use of diuretics
Model III: we adjust age(smooth), gender, SBP(smooth), BMI(smooth), hypertension, diabetes, history of CVD, Hb(smooth), UPCR(smooth), etiology of CKD, eGFR(smooth), use of RAAS inhibitor, urinary occult blood, use of calcium channel blocker, use of diuretics
CI Confidence, Ref Reference, HR Hazard ratios

ISSN: 1471-2369