Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based study

BMC Nephrology

Table 2 Comparison of the prevalence of metabolic syndrome components and chronic kidney disease markers according to thyroid function status

Variables	Thyroid function status			p value
Variables	Subclinical hyperthyroidism (n = 77, 2.5%)	Euthyroidism (n = 3,069, 94.0%)	Subclinical hypothyroidism (n = 111, 3.5%)	p value
Abdominal obesity^a (%)	37.7	29.1	35.1	0.206
Hypertension^b (%)	29.2	32.2	34.6	0.815
Low HDL cholesterol^c (%)	47.0	29.7	40.0	0.003
Elevated triglycerides^d (%)	30.0	30.6	35.9	0.578
Hyperglycemia^e (%)	27.9	30.1	30.7	0.928
eGFR (mL/min/1.73 m²)	101.21 (2.13)	97.90 (0.35)	95.61 (1.49)	0.107
eGFR < 60 mL/min/1.73 m² (%)	1.5	1.5	1.5	0.999
ACR (mg/g)	5.92 (0.68)	15.66 (2.17)	11.16 (1.80)	< 0.001
ACR ≥ 30 mg/g (%)	NA	5.8	11.1	0.020
CKD^f (%)	1.5	6.6	12.6	0.012

MetS, metabolic syndrome; HDL, high-density lipoprotein; BP, blood pressure; eGFR, estimated glomerular filtration rate; ACR, albumin-creatinine ratio; CKD, chronic kidney disease
^aWaist circumference ≥ 90 cm in men and ≥ 80 cm in women; ^bBlood pressure ≥ 130/85 mmHg or antihypertensive medication; ^cHDL cholesterol < 40 mg/dL in men and < 50 mg/dL in women; ^dTriglycerides ≥ 150 mg/dL; ^eFasting glucose ≥ 100 mg/dL, glycated hemoglobin (HbA1c) ≥ 6.5% or antidiabetic medication; ^feGFR < 60 mL/min/1.73 m² or ACR ≥ 30 mg/g.

ISSN: 1471-2369