Table 1 Patients’ characteristics
Average Hb < 10.1 | 10.1 ≤ Average Hb < 11.0 | 11.0 ≤ Average Hb | |||||||
|---|---|---|---|---|---|---|---|---|---|
Baseline | At dialysis | Endpoint | Baseline | At dialysis | Endpoint | Baseline | At dialysis | Endpoint | |
N | 5 | 6 | 6 | ||||||
Term before dialysis (days) | 340.8 ± 32.8 | 283.7 ± 132.0 | 251.7 ± 221.4 | ||||||
Age (years old) | 71.8 ± 10.7 | 62.7 ± 11.2 | 56.3 ± 13.4 | ||||||
Sex (n, (% men)) | 5, (100.0) | 4, (66.7) | 4, (66.7) | ||||||
Diabetes (n, %) | 4, (80.0) | 4, (66.7) | 5, (83.3) | ||||||
Weight (kg) | 59.2 ± 13.4 | 60.4 ± 14.4 | 58.0 ± 11.5 | 68.8 ± 10.4 | 69.0 ± 10.8 | 67.0 ± 10.8 | 64.5 ± 18.2 | 65.2 ± 17.3 | 61.0 ± 12.5 |
SBP (mmHg) | 138.0 ± 14.0 | 141.2 ± 19.7 | 137.6 ± 17.8 | 143.0 ± 13.5 | 143.0 ± 11.5 | 142.0 ± 10.1 | 134.0 ± 9.9 | 128.7 ± 17.4 | 139.2 ± 11.1 |
DBP (mmHg) | 76.5 ± 5.7 | 75.6 ± 12.7 | 73.2 ± 20.0 | 73.5 ± 14.3 | 72.7 ± 11.0 | 72.0 ± 15.9 | 82.5 ± 14.5 | 70.3 ± 9.9 | 85.2 ± 4.1 |
Hemoglobin (g/dL) | 9.6 ± 0.8 | 9.7 ± 0.7 | 10.1 ± 0.8 | 9.5 ± 1.4 | 9.9 ± 0.7 | 10.9 ± 0.5# | 9.9 ± 0.8 | 10.9 ± 0.8* | 12.2 ± 0.8*, **, # |
ERI | 42.0 ± 32.6 | 37.1 ± 16.8 | 33.1 ± 5.2 | 32.7 ± 21.8 | 26.8 ± 14.7 | 29.8 ± 19.4 | 36.1 ± 20.1 | 37.4 ± 20.7 | 23.6 ± 20.8## |
TSAT (%) | 34.5 [30.1, 45.0] | 23.7 [19.4, 43.7] | 20.4 [16.9, 21.2] | 32.8 [29.7, 36.2] | 17.2 [11.6, 38.5] | 31.6 [24.8, 45.0]* | 32.8 [23.3, 44.4] | 17.1 [12.6, 23.1]# | 29.6 [22.2, 62.7] |
Ferritin (mg/dL) | 290 [121, 507] | 176 [69, 256] | 231 [69, 265] | 139 [107, 341] | 193 [62, 537] | 247 [125, 361] | 140 [103, 271] | 122 [68, 310] | 172 [97, 442] |
BNP (pg/mL) | 74 [32, 163] | 482 [106, 1130] | 648 [67, 1189] | 138 [62, 177] | 47 [18, 409] | 269 [153, 343] | 26 [19, 34] | 41 [21, 88] | 50 [19, 191] |
Intact PTH (mg/dL) | 219 [161, 700] | 215 [115, 548] | 320 [156, 648] | 406 [139, 817] | 237 [15, 673] | 141 [93, 282] | 287 [283, 722] | 220 [65, 485] | 161 [93, 320] |
Correction Ca (mg/dL) | 8.7 ± 0.2 | 9.1 ± 0.9 | 9.3 ± 0.7# | 8.8 ± 0.4 | 8.7 ± 0.3 | 8.6 ± 0.2 | 8.6 ± 0.5 | 9.4 ± 0.9 | 9.5 ± 0.8 |
Phosphorus (mg/dL) | 4.2 ± 1.3 | 5.1 ± 1.3 | 5.7 ± 1.1# | 4.4 ± 0.5 | 5.0 ± 1.2 | 5.0 ± 1.5 | 5.7 ± 0.5** | 6.0 ± 1.2 | 5.7 ± 1.7 |
Albumin (mg/dL) | 3.8 ± 0.4 | 3.3 ± 0.5 | 2.9 ± 0.7# | 4.0 ± 0.5 | 3.6 ± 0.4 | 3.6 ± 0.5 | 4.0 ± 0.4 | 3.7 ± 0.4 | 3.5 ± 0.4 |
hsCRP (mg/dL) | 0.07 [0.03, 0.10] | 0.03 [0.01, 0.36] | 0.03 [0.01, 0.14] | 0.28 [0.15, 0.40] | 0.14 [0.09, 0.80] | 0.05 [0.03, 0.06] | 0.09 [0.08, 0.10] | 0.11 [0.06, 5.95] | 0.16 [0.06, 0.30] |
Creatinine (mg/dL) | 4.7 ± 1.7 | 9.3 ± 3.4# | - | 5.7 ± 2.1 | 8.7 ± 1.9# | - | 7.0 ± 0.9* | 10.3 ± 1.9# | - |
Urinary protein (g/g Cr) | 2.3 ± 1.0 | 3.9 ± 4.5 | - | 2.6 ± 1.9 | 1.9 ± 0.6 | - | 1.4 ± 1.1 | 1.5 ± 0.7 | - |
Echocardiography | |||||||||
LVDd (mm) | 52.0 ± 0.1 | 51.7 ± 3.4 | 55.7 ± 7.5 | 49.4 ± 7.2 | 48.9 ± 4.8 | 47.7 ± 3.8 | 49.8 ± 1.1 | 44.6 ± 4.9* | 46.1 ± 4.3* |
Ejection fraction (%) | 0.61 ± 0.19 | 0.60 ± 0.12 | 0.58 ± 0.10 | 0.70 ± 0.15 | 0.67 ± 0.13 | 0.67 ± 0.11 | 0.67 ± 0.01 | 0.71 ± 0.06 | 0.64 ± 0.09## |
LVMI (g/m2) | 163.5 ± 39.6 | 162.7 ± 45.7 | 205.9 ± 41.5 | 143.3 ± 45.3 | 143.1 ± 32.8 | 149.7 ± 25.8* | 117.6 ± 17.7* | 110.5 ± 31.1 | 123.2 ± 29.7* |
RWT | 0.41 ± 0.02 | 0.48 ± 0.06 | 0.44 ± 0.06 | 0.45 ± 0.07 | 0.48 ± 0.04 | 0.50 ± 0.06 | 0.43 ± 0.04 | 0.49 ± 0.05# | 0.48 ± 0.07 |
Treatment (n, (%)) | |||||||||
ARB | 2, (40.0) | 1, (20.0) | 1, (20.0) | 1, (16.7) | 1, (16.7) | 2, (33.3) | 2, (33.3) | 3, (50.0) | 3, (50.0) |
CCB | 1, (20.0) | 1, (20.0) | 1, (20.0) | 0, (0.0) | 0, (0.0) | 1, (16.7) | 3, (50.0) | 3, (50.0) | 4, (66.7) |
β-blocker | 4, (80.0) | 4, (80.0) | 3, (60.0) | 4, (66.7) | 3, (50.0) | 2, (33.3) | 5, (83.3) | 5, (83.3) | 5, (83.3) |