Fig. 4
The protein–protein interaction network analysis was performed using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) software. The nodes reflect individual proteins enriched in the analysis, and the edges are the functional associations based on various online resources. (A) Protein-Protein interaction network of significantly expressed proteins that contains 58 nodes and 153 edges, with a PPI enrichment P-value < 1.0 x 10− 16, line thickness indicates the strength of data support (The thickest edge indicates the highest confidence in protein-protein interaction). (B) Protein-Protein interaction network of top 10 proteins that contains 14 nodes and 15 edges, with a PPI enrichment P-value < 0.008, line color indicates the type of interaction evidence (light blue,known interactions from curated databases; purple, known interactions experimentally determined; green, gene neighborhood; red, gene fusions Blue, gene co-occurrence.)