The Minnesota attributable risk of kidney donation (MARKD) study: a retrospective cohort study of long-term (> 50 year) outcomes after kidney donation compared to well-matched healthy controls

Vock, David M.; Helgeson, Erika S.; Mullan, Aidan F.; Issa, Naim S.; Sanka, Sujana; Saiki, Alison C.; Mathson, Kristin; Chamberlain, Alanna M.; Rule, Andrew D.; Matas, Arthur J.

doi:10.1186/s12882-023-03149-7

Table 2 Data collection sources and frequency for REP controls and UMN donors. CR: Chart Review, DS: Donor survey + chart review if available (every 3 years), SS: Study Survey, LD: Lab data (every year)

From: The Minnesota attributable risk of kidney donation (MARKD) study: a retrospective cohort study of long-term (> 50 year) outcomes after kidney donation compared to well-matched healthy controls

	Source of data
Data	UMN Donors	REP Controls
Baseline characteristics
Demographics	CR	CR¹
History of substance abuse²	CR	CR
Diagnosis of Depression/Anxiety Disorder³	CR	CR
High cholesterol	CR, SS	CR, SS
Hypertension⁴	CR, SS	CR, SS
Family history of kidney disease, DM, HTN	CR, DS, SS	CR, SS
Smoking history	CR, DS, SS	CR, SS
Lab measurements	Requested every 3 years with study survey	Recorded every year if available
BUN/Urea	CR	CR, LD
Glucose	CR	CR, LD
Urine protein⁵	CR	CR, LD
BMI	CR, DS, SS	CR, LD, SS
Creatinine	CR, DS, SS	CR, LD, SS
Blood pressure	CR, DS, SS	CR, LD, SS
Outcomes
CVD⁶	DS, SS	CR, SS
Diabetes	DS, SS	CR, SS
Cancer	DS, SS	CR, SS
Hematuria	DS, SS	CR, SS
High cholesterol treated with medication	DS, SS	CR, SS
Hypertension treated with medication	DS, SS	CR, SS
Pregnancy history⁷	DS, SS	CR, SS
Proteinuria	DS, SS	SS
Kidney disease/ abnormal kidney function/ ESKD	DS, SS, USRDS	CR, SS, USRDS
Vital status and cause of death	DS, SS, NDI	CR⁸, SS, NDI

¹ Chart review for controls includes abstraction of data from electronic transfer from the Rochester Epidemiology Project (REP) database, Mayo clinic paper records, Olmstead Medical Center electronic and paper record, Olmstead Community Hospital electronic and paper records, Epic, and the REP browser (electronic record system) from date of first REP encounter to date of last follow-up
²Permissible substance abuse at donation/donation is defined as a remote history of marijuana use with no active use around the time of the donation date or current marijuana use as long as it does not interfere with lifestyle. Remote other substance use is not a contraindication to donation as long as its truly remote
³Permissible depression/anxiety at donation/donation is defined as well controlled, in the distant past prior to the donation date, or involving few episodes of care
⁴Permissable hypertension at donation/donation includes that which is well controlled (< 140/90), treated with a diuretic antihypetensive agent, a non-diuretic antihypertensive agent, or both (1 diuretic and 1 non-diuretic hypertensive agent), age needs to be > 50 years. Exclude if age < 50 years or not well controlled or using 2 or more non-diuretic agents or using 2 or more diuretic agents
⁵Urine Dipstick, 24 H Urine Protein, Urinalysis Predicted 24-Hour Protein, Protein-Osmolality Ratio, Urine Protein to Creatinine Ratio, Urine Albumin to Creatine Ratio, 24 H Urine Albumin
⁶Congestive heart disease, myocardial infarction, cerebrovascular accident, transient ischemic attack, angioplasty, stents
⁷Number and year of pregnancies, pregnancy outcome (singleton, twins, triplets, ≥ 4, abortion, miscarriage, fetal death), gestational length (full term, pre-term), and pregnancy complications (gestational hypertension, gestational diabetes, proteinuria, eclampsia, preeclampsia)
⁸Proof of life noted for medical encounters with no data

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ISSN: 1471-2369

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