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Fig. 2 | BMC Nephrology

Fig. 2

From: Gaucher disease in a patient with membranoproliferative glomerulonephritis: case report

Fig. 2

A Glomerular mesangial cells and matrix showed severe diffuse hyperplasia; basement membrane was thickened; mesangial matrix was inserted and two-track sign was formed. Gaucher cells were seen in the glomerular capillary. (yellow arrow) (Periodic acid-methenamine silver original magnification×200) (B) Gaucher cells with “crumpled tissue paper” appearance in the glomerular capillary. (yellow arrow) (Periodic acid-schiff stain original magnification×400) (C) EM showed segmental thickening of the basement membrane (about 400-900nm), with segmental mesangial insertion. Electron-dense deposits consisting of both immunoglobulin and C3 were detected in the subendothelial and mesangial regions. Monocytes/macrophages were seen in the lumen of the capillary in the glomerulus. D Twisted microtubules with diameters of approximately 50-80nm could be seen in the lumen of glomerular capillary (red labels). EM=Electron microscope

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