Table 3 Pattern and frequency of drugs with unadjusted doses
Drugs | Drugs which needed dose adjustment No. | Appropriate doses No. (%) | Frequency of inappropriate high doses | Inappropriate high doses No. (%) | ||
|---|---|---|---|---|---|---|
CKD stage 3 No. | CKD stage 4 No. | CKD stage 5 No. | ||||
Antihypertensives | Â | Â | Â | Â | Â | Â |
ACEIs | Â | Â | Â | Â | Â | 37 (56.9) |
Captopril | 25 | 12 (48.0) | Â | 8 | 5 | 13 (52.0) |
Enalapril | 27 | 13 (48.1) | Â | 8 | 6 | 14 (51.8) |
Lisinopril | 13 | 3 (23.0) | Â | 4 | 6 | 10 (76.9) |
ARBs | Â | Â | Â | Â | Â | 32 (55.2) |
Losartan | 27 | 8 (29.6) | Â | 15 | 4 | 19 (70.3) |
Valsartan | 31 | 18 (58.0) | Â | 9 | 4 | 13 (41.9) |
Beta blockers | Â | Â | Â | Â | Â | 41 (56.9) |
Atenolol | 42 | 24 (57.1) | Â | 7 | 11 | 18 (42.8) |
Bisoprolol | 30 | 7 (23.3) | Â | 10 | 13 | 23 (76.6) |
Diuretics | Â | Â | Â | Â | Â | 77 (57.0) |
Hydrochlorothiazide | 84 | 41 (48.8) | Â | 24 | 19 | 43 (51.1) |
Spironolactone | 51 | 17 (33.3) | Â | 18 | 16 | 34 (66.6) |
Antidiabetics | 108 | Â | Â | Â | Â | 64 (59.2) |
Metformin | 33 | 13 (39.3) | 3 | 5 | 12 | 20 (60.6) |
Sitagliptin | 33 | 13 (39.3) | 3 | 5 | 12 | 20 (60.6) |
Gliclazide | 14 | 7 (50.0) | Â | 3 | 4 | 7 (50.0) |
Glimepiride | 12 | 7 (58.3) | Â | 2 | 3 | 5 (41.6) |
Glibenclamide | 16 | 4 (25.0) | Â | 5 | 7 | 12 (75.0) |
Antihyperlipidimics | Â | Â | Â | Â | Â | 30 (46.1) |
Rosuvastatin | 42 | 25 (59.5) | Â | 8 | 9 | 17 (40.4) |
Simvastatin | 23 | 10 (43.4) | Â | 5 | 8 | 13 (56.5) |
NSAIDs + analgesics |  |  |  |  |  | 51 (56.0) |
Aspirin | 19 | 7 (36.8) | Â | 8 | 4 | 12 (63.1) |
Tramadol | 47 | 15 (31.9) | Â | 15 | 17 | 32 (68.0) |
Paracetamol | 25 | 18 (72.0) | Â | 3 | 4 | 7 (28.0) |
Anti-emetics | Â | Â | Â | Â | Â | Â |
Domperidone | 165 | 76 (46.0) | Â | 39 | 50 | 89 (53.9) |
Antibiotics | Â | Â | Â | Â | Â | 19 (79.1) |
Cefixime | 5 | 0 | Â | 3 | 2 | 5 (100.0) |
Ciprofloxacin | 12 | 2 (16.6) | Â | 4 | 6 | 10 (83.3) |
Clarithromycin | 7 | 3 (42.8) | Â | 3 | 1 | 4 (57.1) |