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Table 1 Baseline characteristics of included studies

From: Long-term end-stage renal disease risks after living kidney donation: a systematic review and meta-analysis

Study

Journal

Study type

Data type (single/multi center, claimed data)

Data base

Studied year (Donor)

Exclusion for donor

Studied year (control)

Standard of matching

Exclusion for control

How to calculate GFR

Matched control

Matching variables

Conflict of interests

Lam et al. 2012 [15]

Nephrol Dial Transplant

Retrospective cohort

Claimed data

Cohort study, Canada

1992–2009

none—all donor

1991.7.1-index date

 

Genitourinary disease,

Diabetes,

Hypertension,

Cancer,

Cardiovascular disease,

Pulmonary disease,

Liver disease,

Rheumatological conditions,

Chronic infections,

History of nephrology consultation,

Frequent physician visits (4 / 2yrs),

Failed to see a physician at least once in the two years before the index date

CKD

1:10 matched

Age

Sex

Index date

residence (rural vs. urban)

Income

None

Epidemiology Collaboration (CKD-EPI) equation

Muzaale et al. 2014 [13]

JAMA

Retrospective cohort

Claimed data

Cohort study, United states

1994–2011

none—all donor

1988–1994(enroll)

Healthy non-donor population

Third National Health and Nutrition Examination Survey (NHANES III)—Answered "Yes" to any of these questions by self-report survey

ESRD

1:1 matched

Age, Sex, Race/ethnicity, Education background, BMI at the time of enrollment, History

of cigarette smoking, and SBP

United Network for Organ Sharing

Institutional grant support from the National Institutes of Health

Epidemiology Collaboration (CKD-EPI) equation

Kim et al. 2019 [16]

Renal Epidemiology

Retrospective cohort

Single center

Hospital data

2002–2015

Missing estimated GFR or abdominal US,

A history of cancer,

A history of CKD,

Proteinuria at baseline,

CKD at baseline,

Chronic kidney disease, renal tumor, renal cancer on US

;and/or partial or total nephrectomy due to renal dz

including Renal TB, renal stone, nephritis, renal tumor

2002–2015

 

Same as donor exclusion

Epidemiology Collaboration (CKD-EPI) equation

Simple comparison between the two groups

 

None

Mjoen et al. 2013 [14]

Kidney International

Retrospective cohort

Claimed data

National data

1963–2007

eGFR < 70, Age > 70, Age < 20, BMI > 30, BMI < 17, BP > 140/90, BP medication

1985–1987(enroll)

 

eGFR < 70, Age > 70, Age < 20, BMI > 30, BMI < 17, BP > 140/90, BP medication, Diabetes, CVD, Reduced general health

Epidemiology Collaboration (CKD-EPI) equation

Simple comparison between the two groups

 

None

Haugen et al. 2020 [17]

Transplantation International

Retrospective cohort

Single center

Cohort study

1972–2007

Missing BP baseline/at follow-up,

Age > 70 years,

Use of BP medication,

BMI > 30.0 kg/m2,

BP > 140/90,

CKD-EPI GFR < 70 ml/min/1.73m2,

Fasting glucose > 7 mmol/l

Comorbidity

1984–2013 (enroll)

HUNT surveys

HUNT1 (1984–1986)

HUNT2 (1995–1997)

HUNT3 (2006–2008)

 

Same as donor exclusion

Epidemiology Collaboration (CKD-EPI) equation

General population

 

MSD Europe

AstraZeneca

Boehringer Ingelheim Novo Nordisk Pharma,

Lilly

Sanofi-Aventis

Roche

  1. BMI Body mass index, BP Blood pressure, CKD Chronic kidney disease, CVD Coronary vessel disease, eGFR Estimated Glomerular Filtration Rate, JAMA The Journal of the American Medical Association