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Table 2 End stage renal disease risk of included studies

From: Long-term end-stage renal disease risks after living kidney donation: a systematic review and meta-analysis

 

Journal

N for donor

N for control

Follow up for donor

Follow up for control

Definition of CKD or ESRD

ESRD (or CKD) among donor

ESRD (or CKD) among control

Covariates for HR

Unadjusted HR

Adjusted HR

Cause of ESRD (or CKD) for donor

Cause of ESRD (or CKD) for control

Lam et al. 2012 [15]

Nephrol Dial Transplant

2027

20,270

6.9 (median)

6.5 (median)

ESRD: Acute dialysis in follow-up up period (continuous veno-venous or intermittent)

1

14

  

0.58 (95%CI, 0.08–4.47)

  

Muzaale et al. 2014 [13]

JAMA

96,217

96,217

7.6 [3.9–11.5]

15.0 [13.7–15.0]

ESRD: Earliest of initiation of maintenance dialysis, placement on the waiting list, receipt of a living or deceased donor kidney transplant

99

36

 

2.75 (95% CI, 1.96–3.85)

   

Kim et al. 2019 [16]

Renal Epidemiology

1901

32,621

15.1 [1.5–43.9]

24.9 [0.1–26.0]

CKD: estimated glomerular filtration rate of < 60 ml/min/1.73m2 and/or the presence of proteinuria in two or more consecutive visits

3

2969

Model I

 

13.63 (95%CI, 4.39–42.26)

  

Age,

Sex,

Center,

Year of screening exam

Model II

8.63 (95%CI, 2.78–26.84)

 + Baseline eGFR,

Smoking status,

Alcohol intake,

Regular exercise,

Education level,

Hx of DM, HTN,

Medication use of DM,HTN, Dyslipidemia

Model III

8.72 (95%CI, 2.80–27.12)

 + 

Renal compensation hypertrophy

Mjoen et al. 2013 [14]

Kidney International

1901

32,621

15.1 [1.5–43.9]

24.9 [0.1–26.0]

ESRD: initiation of renal replacement therapy (dialysis, transplantation)

9

22

Inclusion year, Age, Sex, sBP, BMI, Smoking

18.99 (95%CI, 8.63–41.76)

11.38 (95%CI, 4.37–29.63)

Glomerulonephritis (3)

Systemic

lupus erythematosus (1)

Wegner's granulomatosis (1)

ANCA-positive vasculitis (1)

Sarcoidosis(1)

DM/Nephrosclerosis (2)

Glomerulonephritis (5)

Pyelonephritis (4)

PCKD (4)

HTN (3)

DM (1)

Amyloidosis (1)

Systemic lupus erythematosus (1)

Drug induced nephropathy (1)

Medullary

cystic disease (1)

Haugen et al. 2020 [17]

Transplantation International

1029

16,084

11.3 (mean)

16.4 (mean)

CKD: eGFR < 60 ml/min

216

236

 

14.31 (95% CI, 9.71–21.08)

   
  1. BMI Body mass index, CKD Chronic kidney disease, DM Diabetes mellitus, eGFR Estimated Glomerular Filtration Rate, ESRD End stage of renal disease, HR Hazard ratio, HTN Hypertension, JAMA The Journal of the American Medical Association, LKD Living kidney donor, PCKD Polycystic kidney disease, sBP systolic blood pressure