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Table 1 Baseline characteristics of the study groups

From: The effectiveness of sertraline in alleviating uremic pruritus in hemodialysis patients: a randomized clinical trial

 

Sertraline group ( n  = 30)

Placebo group ( n  = 30)

P value

Age (years)

43.67 ± 12.63

50.27 ± 13.09

0.052

Sex (No)

 Male

10 (33.3%)

13 (43.3%)

0.426

 Female

20 (66.7%)

17 (56.7%)

BMI (kg/m2)

26.02 ± 5.80

25.74 ± 4.42

0.833

Pruritis duration (years)

1.70 ± 1.24

1.92 ± 1.50

0.764

Duration of HD (years)

4.69 ± 4.34

4.12 ± 3.38

0.673

Cause of ESRD (No)

 -Hypertension

14

16

 

 -DM

7

3

 -APCKD

2

1

 -GN

5

9

 -Others

2

1

 

Vascular access (No)

 -AV fistula

25 (83.3%)

27 (90%)

0.706

 -Tunneled catheter

5 (16.7%)

3 (10%)

Dialyzer type (No)

 -Low flux

7 (23.3%)

11 (36.7%)

0.260

 -High flux

23 (76.7%)

19 (63.3%)

Comorbidities (No)

 -Hypertension

29

29

 

 -DM

8

6

 

 -IHD

11

18

 

Phosphate binders (No)

 -Calcium Based

17

15

 

 -Non-calcium Based

3

2

 

Alfacalcidol use (No)

11

9

 

Total cholesterol (mg/dl)

184.5 ± 53.25

179.1 ± 27.37

0.564

Serum triglycerides (mg/dl)

122.07 ± 28.89

126.23 ± 39.95

0.941

Hemoglobin (g/dl)

9.98 ± 1.63

9.81 ± 1.63

0.682

Serum albumin (g/dl)

4.17 ± 0.39

3.98 ± 0.79

0.614

SGPT (u/l)

19.27 ± 7.32

18.37 ± 9.54

0.574

Total bilirubin (mg/dl)

0.69 ± 0.20

0.58 ± 0.21

0.064

Serum calcium (mg/dl)

8.31 ± 0.95

8.59 ± 0.77

0.210

Serum phosphorus (mg/dl)

4.65 ± 0.74

4.57 ± 0.53

0.067

Ca X P product

43.12 ± 21.09

38.99 ± 9.22

0.544

Serum PTH (pg/ml)

298.85 ± 120.23

234.73 ± 234.73

0.082

Ferritin (ng/ml)

512.57 ± 269.35

562.27 ± 266.0

0.455

Urea (mg/dl)

148.62 ± 40.20

129.77 ± 36.17

0.061

Creatinine (mg/dl)

11.34 ± 2.54

10.11 ± 3.52

0.125

Kt/V

1.19 ± 0.08

1.17 ± 0.12

0.683

  1. Data were expressed as mean ± standard deviation (SD), or absolute numbers as appropriate
  2. APCKD adult polycystic kidney disease, BMI body mass index, DM diabetes mellitus, ESRD end stage renal disease, GN glomerulonephritis, HD hemodialysis, IHD ischemic heart disease, Kt/V measuring dialysis adequacy, PTH parathyroid hormone, SGPT serum glutamic pyruvic transaminase