Sertraline group ( n = 30) | Placebo group ( n = 30) | P value | |
---|---|---|---|
Age (years) | 43.67 ± 12.63 | 50.27 ± 13.09 | 0.052 |
Sex (No) | |||
Male | 10 (33.3%) | 13 (43.3%) | 0.426 |
Female | 20 (66.7%) | 17 (56.7%) | |
BMI (kg/m2) | 26.02 ± 5.80 | 25.74 ± 4.42 | 0.833 |
Pruritis duration (years) | 1.70 ± 1.24 | 1.92 ± 1.50 | 0.764 |
Duration of HD (years) | 4.69 ± 4.34 | 4.12 ± 3.38 | 0.673 |
Cause of ESRD (No) | |||
-Hypertension | 14 | 16 | |
-DM | 7 | 3 | |
-APCKD | 2 | 1 | |
-GN | 5 | 9 | |
-Others | 2 | 1 | |
Vascular access (No) | |||
-AV fistula | 25 (83.3%) | 27 (90%) | 0.706 |
-Tunneled catheter | 5 (16.7%) | 3 (10%) | |
Dialyzer type (No) | |||
-Low flux | 7 (23.3%) | 11 (36.7%) | 0.260 |
-High flux | 23 (76.7%) | 19 (63.3%) | |
Comorbidities (No) | |||
-Hypertension | 29 | 29 | |
-DM | 8 | 6 | |
-IHD | 11 | 18 | |
Phosphate binders (No) | |||
-Calcium Based | 17 | 15 | |
-Non-calcium Based | 3 | 2 | |
Alfacalcidol use (No) | 11 | 9 | |
Total cholesterol (mg/dl) | 184.5 ± 53.25 | 179.1 ± 27.37 | 0.564 |
Serum triglycerides (mg/dl) | 122.07 ± 28.89 | 126.23 ± 39.95 | 0.941 |
Hemoglobin (g/dl) | 9.98 ± 1.63 | 9.81 ± 1.63 | 0.682 |
Serum albumin (g/dl) | 4.17 ± 0.39 | 3.98 ± 0.79 | 0.614 |
SGPT (u/l) | 19.27 ± 7.32 | 18.37 ± 9.54 | 0.574 |
Total bilirubin (mg/dl) | 0.69 ± 0.20 | 0.58 ± 0.21 | 0.064 |
Serum calcium (mg/dl) | 8.31 ± 0.95 | 8.59 ± 0.77 | 0.210 |
Serum phosphorus (mg/dl) | 4.65 ± 0.74 | 4.57 ± 0.53 | 0.067 |
Ca X P product | 43.12 ± 21.09 | 38.99 ± 9.22 | 0.544 |
Serum PTH (pg/ml) | 298.85 ± 120.23 | 234.73 ± 234.73 | 0.082 |
Ferritin (ng/ml) | 512.57 ± 269.35 | 562.27 ± 266.0 | 0.455 |
Urea (mg/dl) | 148.62 ± 40.20 | 129.77 ± 36.17 | 0.061 |
Creatinine (mg/dl) | 11.34 ± 2.54 | 10.11 ± 3.52 | 0.125 |
Kt/V | 1.19 ± 0.08 | 1.17 ± 0.12 | 0.683 |