Extracellular status of thrombospondin-2 in type 2 diabetes mellitus and utility as a biomarker in the determination of early diabetic kidney disease

Table 2 Correlation between serum TSP-2 (log transformed) with various parameters (n = 494)

	Serum TSP-2 ^a		Serum TSP-2^a (age-adjusted)		Serum TSP-2^a (age, sex, and T2DM duration-adjusted)
Variables	r	p	r	p	r	p
Age	0.063	0.163	—	—	—	—
Sex	-0.006	0.867	-0.009	0.845	—	—
Current smoking	0.068	0.066	0.075	0.096	0.081	0.075
Physical activity	0.039	0.285	0.044	0.335	0.041	0.364
Hypertension	0.033	0.367	0.035	0.442	0.034	0.453
No antidiabetic therapy	-0.026	0.474	-0.040	0.378	-0.029	0.524
Insulin + OHA	-0.008	0.819	-0.012	0.782	-0.024	0.602
T2DM duration	0.051	0.263	0.032	0.484	—	—
BMI	0.068	0.134	0.073	0.109	0.073	0.108
FPG^a	0.030	0.503	0.035	0.466	0.036	0.435
HbA1c^a	-0.023	0.619	-0.006	0.891	-0.006	0.892
SBP	0.104	0.022	0.090	0.049	0.087	0.055
DBP	0.085	0.060	0.087	0.055	0.088	0.053
TG^a	0.098	0.030	0.109	0.016	0.109	0.016
TC^a	0.026	0.566	0.036	0.425	0.039	0.393
HDL-c^a	-0.031	0.491	-0.044	0.338	-0.043	0.343
LDL-c^a	-0.017	0.710	-0.007	0.874	-0.005	0.916
SUA^a	0.135	0.003	0.144	0.002	0.145	0.001
BUN^a	0.024	0.593	0.006	0.893	0.005	0.912
SCR^a	0.104	0.021	0.101	0.025	0.113	0.013
eGFR^a	-0.127	0.005	-0.111	0.014	-0.112	0.014
Albumin^a	-0.058	0.203	-0.044	0.335	-0.048	0.294
Platelets^a	0.098	0.030	0.095	0.037	0.095	0.036
UACR^a	0.339	< 0.001	0.334	< 0.001	0.344	< 0.001

OHA Oral hypoglycemic agent, BMI Body mass index, FPG Fasting plasma glucose, HbA1c Hemoglobin A1c, SBP Systolic blood pressure, DBP Diastolic blood pressure, TG Triglyceride, TC Total cholesterol, HDL-c High-density lipoprotein cholesterol, LDL-c Low-density lipoprotein cholesterol, SUA Serum uric acid, BUN Blood urea nitrogen, SCR Serum creatinine, eGFR Estimated glomerular filtration rate, UACR Urinary albumin-to-creatinine ratio
^aLog transformed

ISSN: 1471-2369