Table 2 Humoral immune response after vaccination at V1, V2, V3, and V4
Humoral immune response | Value | p-value* |
|---|---|---|
Anti-sRBD IgG antibody (U/mL), GMT (95%CI) | ||
Baseline (V1) | 2.98 (1.20–7.42) | Ref |
1 month after primary vaccination (V2) | 332.66 (197.24–561.05) | V1 vs V2: < 0.0001 |
8 months after primary vaccination (V3) | 5,296.63 (2,930.89–9,571.94) | V1 vs V3: < 0.0001 V2 vs V3: < 0.0001 |
1 month after the booster (V4) | 19,142.56 (13,489.63–27,227.01) | V1 vs V4: < 0.0001 V2 vs V4: < 0.0001 V3 vs V4: < 0.0001 |
Anti-sRBD IgG antibody (U/mL), GMFR (95%CI) | ||
ΔGMFR V2 vs. V1 | 111.69 (26.42–145.55) | NA |
GMFR V3 vs. V1 | 1,782.38 (2.19–158,854.68) | NA |
GMFR V4 vs. V1 | 6,426.88 (1,256.03–11,428.78) | NA |
sVNT NAbs (% inhibition), Median (IQR) | ||
Baseline (V1) | 15 (9–83.75) | Ref |
1 month after primary vaccination (V2) | 84 (70.50–96) | V1 vs V2: 0.0308 |
8 months after primary vaccination (V3) | 97 (93.50–98) | V1 vs V3: < 0.0001 V2 vs V3: 0.0044 |
1 month after the booster (V4) | 97 (96.75–98) | V1 vs V4: < 0.0001 V2 vs V4: 0.0007 V3 vs V4: > 0.9999 |