Fig. 5

Knockdown of FXR sensitized HK2 cells to AGE-induced apoptosis. A Immunoblotting showed that siFXR effectively knocked down FXR in HK2 cells. B FXR knockdown aggravated AGE-induced activation of caspase-3 and PARP-1, as shown by an increase in their cleaved forms. All the results represent the data from three independent experiments. *p < 0.05; **p < 0.01; ^##p < 0.01, statistical significance