Fig. 3

Decline in eGFR during the on-treatment and off-treatment periods. a Cohort 1; b Cohort 2. The estimations were calculated from the piecewise-mixed model using the mean baseline eGFR (shown as a blue circle at time 0) in the analysis set. The estimations during the on-treatment period (the green line segment) started at the first postbaseline assessment and ended at the mean duration of the tolvaptan treatment. For the off-treatment period (the red line segment), the estimations were calculated for the mean follow-up (off-treatment) time. The gap between the green and red line segments reflected the estimated reverse of hemodynamic effect following tolvaptan discontinuation. CI, confidence interval; eGFR, estimated glomerular filtration rate