Table 1 Patient baseline characteristics
Cohort 1 ≥ 2 on treatment, ≥ 2 post-treatment assessments | Cohort 2 ≥ 1 on treatment, ≥ 1 post-treatment assessments | ||||
|---|---|---|---|---|---|
Characteristic | Statistic or Category | eGFR Analysis (n = 20) | TKV Analysis (n = 11) | eGFR Analysis (n = 82) | TKV Analysis (n = 88) |
Age, years | Mean (SD) | 39.9 (8.5) | 40.9 (8.1) | 40.3 (7.4) | 40.7 (7.2) |
Median | 41.2 | 41.3 | 41.1 | 41.5 | |
Min, Max | 23.6, 50.2 | 23.6, 50.2 | 23.6, 52.1 | 23.6, 51.9 | |
Sex | Male | 6 (30%) | 3 (27%) | 40 (49%) | 43 (49%) |
Female | 14 (70%) | 8 (73%) | 42 (51%) | 45 (51%) | |
Race | White | 19 (95%) | 11 (100%) | 76 (93%) | 80 (91%) |
Black | 1 (5%) | 0 | 3 (4%) | 4 (5%) | |
Hispanic | 0 | 0 | 3 (4%) | 4 (5%) | |
Other | 0 | 0 | 0 | 0 | |
Height, m | Mean (SD) | 1.72 (0.11) | 1.72 (0.11) | 1.73 (0.11) | 1.74 (0.11) |
Weight, kg | Mean (SD) | 77.1 (16.6) | 77.7 (18.3) | 78.3 (16.9) | 79.5 (17.3) |
Body mass index, kg/m2 | Mean (SD) | 25.8 (3.5) | 25.9 (3.3) | 26.0 (4.3) | 26.2 (4.6) |
Age at ADPKD diagnosis, years | Mean (SD) | 27.7 (9.6) | 25.5 (8.2) | 27.3 (9.3) | 27.6 (9.1) |
Chronic kidney disease stage, mL/min/1.73 m2 | ≥ 90 (stage G1) | 10 (50%) | 5 (50%) | 29 (35%) | 22 (25%) |
60 to < 90 (stage G2) | 5 (25%) | 1 (10%) | 32 (39%) | 37 (43%) | |
30 to < 60 (stage G3) | 5 (25%) | 4 (40%) | 21 (26%) | 28 (32%) | |
< 30 (stage G4) | 0 | 0 | 0 | 0 | |
Baseline eGFR, mL/min/1.73 m2 | Mean (SD) | 84 (26) | 82 (27) | 80 (22) | 75 (22) |
Min, Max | 44, 122 | 45, 116 | 36, 126 | 34, 126 | |
Systolic blood pressure, mmHg | Mean (SD) | 127.0 (13.1) | 125.0 (11.6) | 125.4 (11.6) | 124.7 (11.7) |
Diastolic blood pressure, mmHg | Mean (SD) | 80.3 (9.6) | 81.2 (11.2) | 79.6 (7.9) | 79.8 (8.7) |
TKV, mL | Mean (SD) | 2109 (1467) | 1828 (792) | 1876 (1120) | 1897 (1074) |
Min, Max | 836, 6958 | 873, 3436 | 572, 6958 | 416, 6958 | |
ADPKD risk classification | Class 1A | 0 | 0 | 0 | 1 (1%) |
Class 1B | 2 (10%) | 1 (9%) | 10 (12%) | 8 (9%) | |
Class 1C | 5 (25%) | 3 (27%) | 25 (31%) | 32 (36%) | |
Class 1D | 8 (40%) | 4 (36%) | 31 (38%) | 31 (35%) | |
Class 1E | 5 (25%) | 3 (27%) | 16 (20%) | 16 (18%) | |