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Table 1 Relevant laboratory findings

From: Hemophagocytic lymphohistiocytosis secondary to virus infection and followed by lupus nephritis recurrence in a renal transplantation pediatric recipient: a case report

 

Stage1 (Anemia)

Stage2 (Fever)

Stage3 (Hematuria)

Discharge

Follow-up

Normal range

Complete blood cell count

      

WBC count (109/L)

3.71

2.91

8.53

7.63

8.31

5–12

Absolute neutrophil count (109/L)

2.15

1.92

6.03

5.02

4.54

1.8–6.3

Hemoglobin (g/l)

72

56

102

114

111

110–160

Platelet count (109/L)

152

153

196

168

230

100–400

Chemistry

      

Creatinine (umol/l)

68

66.2

78

65

80

44–133

BUN (mmol/l)

9.48

3.82

21

19.6

5.7

2.9–7.14

Uric acid (umol/l)

239.7

279

334

330

187

155–357

Urinary analysis

      

protein

Negative

Negative

+

 

Negative

 

Leukocyte esterase

Negative

Negative

Negative

 

Negative

 

Glucose

Negative

Negative

+-

 

+-

 

Occult blood

Negative

Negative

+++

 

+

 

RBC (/HP)

0

0

+++

  

0

WBC (/HP)

0

0–1

0

  

0–3

24-h urine protein (mg/day)

  

1573.11

  

0-150

Urine culture

  

Proteus mirabilis

Negative

  

Immune serologies

      

C1q

 

2.3

5.32

  

<10

ANA (1: 80)

 

Positive

Negative

   

ANA (1: 160)

 

Positive

Negative

   

ANA (1: 320)

 

Negative

Negative

   

Anti-dsDNA

 

Positive

Negative

   

Anti-SM

 

Negative

    

C3 (g/l)

 

0.55

0.46

  

0.79–1.52

C4 (g/l)

 

0.18

0.12

  

0.16–0.38

ESR (mm/h)

 

9

   

0–20

Anemia-related tests

      

Serum vitamin B12 (pg/ml)

554

    

187–883

Olic acid (ng/ml)

>20

    

3.1–20.5

Thalassemia gene test

Negative

     

Sucrose hemolysis test

Negative

     

Direct anti-human globulin (IgG) test

Negative

     

Direct anti-human globulin (C3) test

Negative

     

TRF (g/l)

 

1.03

   

2.02–3.36

Infectious tests

      

CRP (mg/l)

 

2.07

   

0–8

PCT (ng/ml)

 

0.126

0.058

  

0-0.05

G text

 

78.5

<37.5

  

<70

GM text

 

0.02

   

<0.5

Blood culture

 

Negative

    

Bone marrow culture

 

Negative

    

Virus DNA quantification

      

CMV-DNA (copies/ml)

Negative

Negative

142

  

<500

B19-DNA (ct)

7.21

4.57

31.3

  

>38

JCV-DNA (copies/ml)

Negative

    

<2.0E + 03

BKV-DNA (copies/ml)

Negative

 

Negative

  

<2.0E + 03

EBV-DNA(copies/ml)

22.66

1.27E + 03

Negative

393.2

 

<500

 EBV-DNA in B cells (copies/105cells)

 

18.21

    

 EBV-DNA in T cells (copies/105cells)

 

45.3

    

 EBV-DNA in NK cells (copies/105cells)

 

Negative

    

HLH-specific tests

      

Fibrinogen (g/l)

 

1.94

1.76

  

2–4

Triglyceride (mmol/l)

 

1.91

0.73

  

<1.71

Ferritin (ng/l)

332.9

622.9

99.71

  

4.63–204

Soluble interleukin-2 receptor (u/ml)

 

2903

   

223–710

Natural killer cell activity (pg/ml)

 

2.55%

    

Genetic testing for HLH

 

Negative

    
  1. WBC, white blood cell; BUN, blood urea nitrogen; RBC, red blood cell; C1q, complement component 1q; ANA, antinuclear antibody; Anti-dsDNA, anti-double stranded deoxyribonucleic acid; C3, complement 3; C4, complement 4; ESR, erythrocyte sedimentation Rate; TRF, transferrin; CRP, c-reactive protein; PCT, procalcitonin; GM, glactomannan; DNA, deoxyribonucleic acid; JCV, John Cunningham virus; BKV, BK virus; EBV, Epstein-Barr virus; NK, natural killer; HLH, hemophagocytic lymphohistiocytosis
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BMC Nephrology

ISSN: 1471-2369

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