From: Impact of serum sodium concentrations, and effect modifiers on mortality in the Irish Health System
 | Serum Sodium Category | P-interaction | ||
---|---|---|---|---|
Variable |  < 135 mmol/L HR (95%CI) | 135–145 mmol/L HR (95%CI) |  > 145 mmol/L HR (95%CI) |  |
Model with eGFR interaction |  |  |  |  < 0.001 |
 eGFR >  = 60 ml/min/1.72m2 | 2.28 (2.04–2.51) | 1.00 (Ref.) | 3.28 (2.19–4.72) |  |
 eGFR < 60 ml/min/1.72m2 | 1.31 (1.13–1.49) | 1.00 (Ref.) | 2.02 (1.44–2.68) |  |
Model with age interaction |  |  |  |  < 0.001 |
 Age 40 | 3.33 (2.72–4.02) | 1.00 (Ref.) | 6.96 (3.98–10.76) |  |
 Age 50 | 2.67 (2.31–3.07) | 1.00 (Ref.) | 4.85 (3.16–6.75) |  |
 Age 60 | 2.14 (1.93–2.35) | 1.00 (Ref.) | 3.40 (2.55–4.34) |  |
 Age 70 | 1.72 (1.58–1.85) | 1.00 (Ref.) | 2.40 (1.91–2.96) |  |
 Age 80 | 1.38 (1.25–1.50) | 1.00 (Ref.) | 1.70 (1.27–2.23) |  |
Model with Clinical setting interaction |  |  |  |  < 0.001 |
 Emergency Department | 1.19 (0.99–1.41) | 1.00 (Ref.) | 3.09 (1.89–4.88) |  |
 General Practice | 2.70 (2.15–3.36) | 1.00 (Ref.) | 3.13 (1.20–5.46) |  |
 Inpatient | 1.69 (1.50–1.89) | 1.00 (Ref.) | 1.61 (1.15–2.17) |  |
 Outpatient | 1.90 (1.54–2.31) | 1.00 (Ref.) | 9.84 (4.88–18.62) |  |