Skip to main content

Table 3 Interactions between Sodium category, eGFR, age and clinical setting at baseline on all-cause mortality

From: Impact of serum sodium concentrations, and effect modifiers on mortality in the Irish Health System

 

Serum Sodium Category

P-interaction

Variable

 < 135 mmol/L

HR (95%CI)

135–145 mmol/L

HR (95%CI)

 > 145 mmol/L

HR (95%CI)

 

Model with eGFR interaction

   

 < 0.001

 eGFR >  = 60 ml/min/1.72m2

2.28 (2.04–2.51)

1.00 (Ref.)

3.28 (2.19–4.72)

 

 eGFR < 60 ml/min/1.72m2

1.31 (1.13–1.49)

1.00 (Ref.)

2.02 (1.44–2.68)

 

Model with age interaction

   

 < 0.001

 Age 40

3.33 (2.72–4.02)

1.00 (Ref.)

6.96 (3.98–10.76)

 

 Age 50

2.67 (2.31–3.07)

1.00 (Ref.)

4.85 (3.16–6.75)

 

 Age 60

2.14 (1.93–2.35)

1.00 (Ref.)

3.40 (2.55–4.34)

 

 Age 70

1.72 (1.58–1.85)

1.00 (Ref.)

2.40 (1.91–2.96)

 

 Age 80

1.38 (1.25–1.50)

1.00 (Ref.)

1.70 (1.27–2.23)

 

Model with Clinical setting interaction

   

 < 0.001

 Emergency Department

1.19 (0.99–1.41)

1.00 (Ref.)

3.09 (1.89–4.88)

 

 General Practice

2.70 (2.15–3.36)

1.00 (Ref.)

3.13 (1.20–5.46)

 

 Inpatient

1.69 (1.50–1.89)

1.00 (Ref.)

1.61 (1.15–2.17)

 

 Outpatient

1.90 (1.54–2.31)

1.00 (Ref.)

9.84 (4.88–18.62)

 
  1. Final Model was adjusted for baseline age, sex, eGFR, albumin, haemoglobin, potassium, calcium, white blood cell count, alanine aminotransferase, alkaline phosphatase and clinical setting at baseline