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Fig. 3 | BMC Nephrology

Fig. 3

From: A report of three cases of patients with tubulointerstitial nephritis with IgM-positive plasma cells, treatment, and serum-IgM as a sensitive marker for relapse

Fig. 3

The renal biopsy specimen from case 3 contained 39 glomeruli, 5 with global sclerosis but no major glomerular changes. a Periodic acid-Schiff (PAS) stain (100 ×), showed inflammatory cell infiltrate in tubules and interstitium. b PAS stain (400 ×) revealed that the inflammatory cells included lymphocytes and plasma cells (yellow arrows). Immunohistochemistry for (c) IgM (200 ×), and (d) CD38 (200 ×) revealed the presence of many IgM-positive plasma cells in tubules and interstitium. The average number of IgM-PCs per HPF in three HPFs was 13. e Clinical course in case 3: After the patient started on treatment with prednisolone (PSL 30 mg daily: 0.4 mg/kg/day) for 4 weeks, markers decreased immediately. We gradually tapered PSL to 15 mg daily (0.2 mg/kg/day) as shown here; however, serum IgM levels increased again, and PSL was continued at 15 mg daily (0.2 mg/kg/day)

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BMC Nephrology

ISSN: 1471-2369

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